Allyloxypolyethyleneglycol

Base Information

• Chemical Name: Allyloxypolyethyleneglycol
• CAS No.: 27274-31-3
• Molecular Formula: C₉H₁₈O₄
• Molecular Weight: 190.24
• European Community (EC) Number: 203-871-7,608-071-5,936-588-9
• NSC Number: 32614
• UNII: 852300B9QS
• DSSTox Substance ID: DTXSID0059401
• Nikkaji Number: J38.384H
• Wikidata: Q27896790
• Mol file: 27274-31-3.mol

Synonyms:Glycols,polyethylene, monoallyl ether (8CI);Poly(oxy-1,2-ethanediyl), a-2-propenyl-w-hydroxy- (9CI);AE 1100;AE 20;APEG 350;Adeka Carpol LX 1383;Breox AA-PE 554H;F 6;F 6 (polyoxyalkylene);HMX 23;Nissan Uniox A 450R;Nissan Uniox PKA 5002;Nissan Uniox PKA 5003;Pluriol A 010R;Polyglycol20-10;Polyglycol A 1100;Polyglycol A 550;Polyoxyethylene monoallyl ether;Rhodasurf AAE;Rhodasurf AAE 10;SGG 01201;Uniox A 450R;Uniox PKA 5004;a-2-Propenyl-w-hydroxypoly(oxy-1,2-ethanediyl);a-Allyl-w-hydroxy poly(ethylene oxide);

Chemical Property of Allyloxypolyethyleneglycol

Chemical Property:

• Melting Point: 20-25°C
• Refractive Index: 1.465
• Boiling Point: 90.2oC at 760mmHg
• Flash Point: 4.4oC
• PSA: 0.00000
• Density: 0.762g/cm3
• LogP: 0.00000
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 102.068079557
• Heavy Atom Count: 7
• Complexity: 43.3

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CCOCCO

Technology Process of Allyloxypolyethyleneglycol

There total 61 articles about Allyloxypolyethyleneglycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Methyl (2-allyloxy-ethoxy)-acetate (1352078-72-8) → 2-(2-allyloxyethoxy)ethanol (15075-50-0,27274-31-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 95.0%

ethylene glycol (107-21-1) + allyl bromide (106-95-6) → ethylene glycol monoallyl ether (111-45-5,27274-31-3)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; for 3h;

Reference yield: 92.0%

allyl bromide (106-95-6) + diethylene glycol (111-46-6) → 2-(2-allyloxyethoxy)ethanol (15075-50-0,27274-31-3)

Guidance literature:

With copper; In N,N-dimethyl-formamide; Heating;

upstream raw materials:

oxirane

allyl alcohol

ethylene glycol

2-vinyl-1,3-dioxolane

Downstream raw materials:

maleic acid-(2-allyloxy-ethyl ester)-methyl ester

2-(allyloxy)ethyl bromide

acetic acid 2-allyloxyethyl ester

phthalic acid bis-(2-allyloxy-ethyl ester)

Refernces

• 1、 -. "Chain extender as well as preparation method and application thereof". Paragraph 0038; 0041; 0043; 0046; 0048; 0051. . Retrieved 2022/01/20.
• 2、 Zoppi, Vittoria,Hughes, Scott J.,Maniaci, Chiara,Testa, Andrea,Gmaschitz, Teresa,Wieshofer, Corinna,Koegl, Manfred,Riching, Kristin M.,Daniels, Danette L.,Spallarossa, Andrea,Ciulli, Alessio. "Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7". . p. 699 - 726. Retrieved 2019/01/11.