2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

Base Information

Chemical Name:2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid
CAS No.:1328998-09-9
Molecular Formula:C₁₈H₁₇F₂NO₅S
Molecular Weight:397.399
Hs Code.:

Synonyms:2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

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Chemical Property of 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

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Technology Process of 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

There total 5 articles about 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 367-27-1
2,4-difluorophenol

: 1328998-12-4
(2,4-Difluoro-phenoxy)-[3-(pyrrolidine-1-sulfonyl)-phenyl]-acetic acid

: 1328998-09-9
2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

Guidance literature:: bromo-phenyl-acetic acid methyl ester; With chlorosulfonic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

pyrrolidine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

2,4-difluorophenol;

Reference yield:

: 1328998-06-6
methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

: 1328998-09-9
2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 1328998-04-4
methyl 2-bromo-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

: 1328998-09-9
2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; methanol; water / 18 h / 20 °C / Inert atmosphere

With caesium carbonate; lithium hydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042