methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

Base Information

Chemical Name:methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate
CAS No.:1328998-06-6
Molecular Formula:C₁₉H₁₉F₂NO₅S
Molecular Weight:411.426
Hs Code.:

Synonyms:methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

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Chemical Property of methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

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Technology Process of methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

There total 4 articles about methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 367-27-1
2,4-difluorophenol

: 1328998-07-7
(2,4-difluoro-phenoxy)-[3-(pyrrolidine-1-sulfonyl)-phenyl]-acetic acid methyl ester

: 1328998-06-6
methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

Guidance literature:: bromo-phenyl-acetic acid methyl ester; With chlorosulfonic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

pyrrolidine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

2,4-difluorophenol;

Reference yield:

: 367-27-1
2,4-difluorophenol

: 1328998-04-4
methyl 2-bromo-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

: 1328998-06-6
methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

Guidance literature:: With caesium carbonate; In acetonitrile; at 25 ℃; for 3.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2017.03.042

Reference yield:

: 91361-92-1
(4-mercapto-phenyl)-acetic acid methyl ester

: 1328998-06-6
methyl 2-(2,4-difluorophenoxy)-2-(4-pyrrolidin-1-ylsulfonylphenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium nitrate; chloro-trimethyl-silane / dichloromethane / 50 °C / Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux; Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate / acetonitrile / 3.5 h / 25 °C / Inert atmosphere

With N-Bromosuccinimide; chloro-trimethyl-silane; caesium carbonate; potassium nitrate; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2017.03.042