methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

Base Information

Chemical Name:methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate
CAS No.:602280-49-9
Molecular Formula:C₂₁H₁₅Cl₂N₃O₇
Molecular Weight:492.272
Hs Code.:

Synonyms:methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

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Chemical Property of methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

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Technology Process of methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

There total 3 articles about methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1955-46-0
5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

: 602280-49-9
methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70 percent / BH₃*THF / tetrahydrofuran / -10 - 64 °C

2.1: 78 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.75 h / -78 °C

3.1: CH₂Cl₂ / 16 h / 20 °C

3.2: chlorobenzene / 16 h / 80 °C

With borane-THF; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030131l

Reference yield:

: 53732-08-4
3-hydroxymethyl-5-nitrobenzoic acid methyl ester

: 602280-49-9
methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 78 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.75 h / -78 °C

2.1: CH₂Cl₂ / 16 h / 20 °C

2.2: chlorobenzene / 16 h / 80 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/jm030131l

Reference yield:

: 79-37-8
oxalyl dichloride

: 7677-24-9
trimethylsilyl cyanide

: 1738-68-7
Gly-OBz

: 172899-78-4
methyl 3-formyl-5-nitrobenzoate

: 602280-49-9
methyl 3-{1-[2-(benzyloxy)-2-oxoethyl]-3,5-dichloro-6-oxo-1,6-dihydropyrazin-2-yl}-5-nitrobenzoate

Guidance literature:: trimethylsilyl cyanide; Gly-OBz; methyl 3-formyl-5-nitrobenzoate; In dichloromethane;

oxalyl dichloride; In 1,2-dichloro-benzene;
DOI:10.1016/S0960-894X(03)00410-4