Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester

Base Information

• Chemical Name: Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester
• CAS No.: 137105-31-8
• Molecular Formula: C₂₉H₃₃NO₅
• Molecular Weight: 475.585
• Mol file: 137105-31-8.mol

Synonyms:Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester

Chemical Property of Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester

There total 4 articles about Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(-)-2-(benzyloxy)-3-hydroxypropyl benzoate (109430-97-9) + p-pivalolaminobenzyl 2,2,2-trichloroacetimidate (137105-38-5) → Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester (137105-31-8)

Guidance literature:

trifluorormethanesulfonic acid; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1016/0040-4039(91)80616-E

Reference yield:

4-aminobenzenemethanol (623-04-1) → Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester (137105-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

2: 95 percent / Cs₂CO₃ / CH₂Cl₂ / Ambient temperature

3: 82 percent / CF₃SO₃H / CH₂Cl₂ / 1.5 h / Ambient temperature

With caesium carbonate; triethylamine; trifluorormethanesulfonic acid; In dichloromethane;

DOI:10.1016/0040-4039(91)80616-E

Reference yield:

pivaloyl chloride (3282-30-2) → Benzoic acid (S)-2-benzyloxy-3-[4-(2,2-dimethyl-propionylamino)-benzyloxy]-propyl ester (137105-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

2: 95 percent / Cs₂CO₃ / CH₂Cl₂ / Ambient temperature

3: 82 percent / CF₃SO₃H / CH₂Cl₂ / 1.5 h / Ambient temperature

With caesium carbonate; triethylamine; trifluorormethanesulfonic acid; In dichloromethane;

DOI:10.1016/0040-4039(91)80616-E

upstream raw materials:

(-)-2-(benzyloxy)-3-hydroxypropyl benzoate

p-pivalolaminobenzyl 2,2,2-trichloroacetimidate

4-aminobenzenemethanol

pivaloyl chloride