Technology Process of N-(2',4'-difluoro-5-(5-iodo-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide
There total 10 articles about N-(2',4'-difluoro-5-(5-iodo-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
at 100 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C
2: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C
3: 0.5 h / 100 °C
With
potassium fluoride; ammonium chloride; zinc;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: acetic acid; iron / acetic acid / 0.5 h / 90 °C
2: 0.5 h / 0 - 20 °C
3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere
5: potassium fluoride / N,N-dimethyl-formamide / 5 h / 130 °C
6: ammonium chloride; zinc / water; tetrahydrofuran / 0.5 h / 20 °C
7: 0.5 h / 100 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; palladium 10% on activated carbon; hydrogen; iron; sodium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
