(Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

Base Information

• Chemical Name: (Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate
• CAS No.: 1332478-75-7
• Molecular Formula: C₁₃H₉F₂NO₄
• Molecular Weight: 281.216
• Mol file: 1332478-75-7.mol

Synonyms:(Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

Chemical Property of (Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

There total 1 articles about (Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

acetic anhydride (108-24-7) + 3,5-difluoro-4-hydroxybenzaldehyde (118276-06-5) + N-acetylglycine (543-24-8) → (Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate (1332478-75-7)

Guidance literature:

With sodium acetate; at 110 ℃; for 5h;

DOI:10.1002/anie.201914576

Reference yield: 78.0%

(Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate (1332478-75-7) + (1H-benzo[d]imidazol-4-yl)methanamine hydrochloride → (Z)-3-((1H-benzo[d]imidazol-4-yl)methyl)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3,5-dihydro-4Himidazol-4-one

Guidance literature:

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; at 100 ℃;

DOI:10.1002/anie.201914576

Reference yield: 60.0%

(Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate (1332478-75-7) + methylamine (74-89-5) → (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one (1241390-29-3)

Guidance literature:

With potassium carbonate; In ethanol; water; for 4h; Reflux;

DOI:10.1021/ja410819x

upstream raw materials:

acetic anhydride

3,5-difluoro-4-hydroxybenzaldehyde

N-acetylglycine

Downstream raw materials:

(Z)-1-(2-aminoethyl)-4-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-1Himidazol-5(4H)-one

(Z)-4-(3,5-difluoro-4-hydroxybenzylidene)-1-hydroxy-2-methyl-1Himidazol-5(4H)-one

(Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

(Z)-4-(3,5-difluoro-4-hydroxybenzylidene)-1-methoxy-2-methyl-1Himidazol-5(4H)-one