(Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

Base Information

• Chemical Name: (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one
• CAS No.: 1241390-29-3
• Molecular Formula: C₁₂H₁₀F₂N₂O₂
• Molecular Weight: 252.22
• Mol file: 1241390-29-3.mol

Synonyms:(Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

Chemical Property of (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

DHFBI ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: DHFBI mimics a green fluorescent protein in the use of biological assays and drug development.

Technology Process of (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one

There total 3 articles about (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate (1332478-75-7) + methylamine (74-89-5) → (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one (1241390-29-3)

Guidance literature:

With potassium carbonate; In ethanol; water; for 4h; Reflux;

DOI:10.1021/ja410819x

Reference yield:

pyrrolidine (123-75-1) + methanol (67-56-1) + 3,5-difluoro-4-hydroxybenzaldehyde (118276-06-5) + methylamine (74-89-5) → (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one (1241390-29-3)

Guidance literature:

pyrrolidine; 3,5-difluoro-4-hydroxybenzaldehyde; methylamine; With sodium sulfate; In chloroform; water; at 20 ℃; for 48h;

methanol; With ethyl ((methoxy)amino)acetate; at 20 ℃; for 24h;

DOI:10.1002/chem.201901151

Reference yield:

3,5-difluoro-4-hydroxybenzaldehyde (118276-06-5) → (Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one (1241390-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / 1 h / 100 °C

2: potassium carbonate / ethanol; water / 4 h / Reflux

With sodium acetate; potassium carbonate; In ethanol; water;

DOI:10.1021/ja410819x

upstream raw materials:

3,5-difluoro-4-hydroxybenzaldehyde

(Z)-2,6-difluoro-4-((2-methyl-5-oxooxazol-4(5H)-ylidene)methyl)phenyl acetate

methylamine

pyrrolidine