2,2-diiodo-1-(4-methoxyphenyl)ethanone

Base Information

• Chemical Name: 2,2-diiodo-1-(4-methoxyphenyl)ethanone
• CAS No.: 1374568-26-9
• Molecular Formula: C₉H₈I₂O₂
• Molecular Weight: 401.97
• Mol file: 1374568-26-9.mol

Synonyms:2,2-diiodo-1-(4-methoxyphenyl)ethanone

Chemical Property of 2,2-diiodo-1-(4-methoxyphenyl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-diiodo-1-(4-methoxyphenyl)ethanone

There total 3 articles about 2,2-diiodo-1-(4-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

α-(diiodomethyl)-4-methoxybenzenemethanol (265999-47-1) → 2,2-diiodo-1-(4-methoxyphenyl)ethanone (1374568-26-9)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 19h;

DOI:10.1002/ejoc.201101835

Reference yield: 65.0%

1-(4-methoxyphenyl)ethanone (100-06-1) → 2,2-diiodo-1-(4-methoxyphenyl)ethanone (1374568-26-9)

Guidance literature:

With iodine; In nitromethane; at 120 ℃; for 1h; regioselective reaction; Sealed tube;

DOI:10.1002/cctc.201701182

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2,2-diiodo-1-(4-methoxyphenyl)ethanone (1374568-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropylmagnesium chloride / tetrahydrofuran / -78 - 0 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 19 h / 20 °C

With isopropylmagnesium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/ejoc.201101835

upstream raw materials:

4-methoxy-benzaldehyde

α-(diiodomethyl)-4-methoxybenzenemethanol

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

2-(4-methoxyphenyl)quinoxaline

p-methoxyphenylglyoxal