2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Base Information Edit

Chemical Name:2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
CAS No.:21679-15-2
Molecular Formula:C₁₀H₁₂FN₅O₄
Molecular Weight:285.235
Hs Code.:
NSC Number:124463,118218,108524,30605
DSSTox Substance ID:DTXSID30274398,DTXSID60860268
ChEMBL ID:CHEMBL598
Mol file:21679-15-2.mol

Synonyms:2-fluoroadenine arabinoside;9-beta-D-arabinofuranosyl-2-fluoroadenine;9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro-;F-ara-A;fludarabine

Suppliers and Price of 2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
9-A-D-ARABINOFURANOSYL-2-FLUOROADENINE 95.00%
5MG
$ 502.90

Total 3 raw suppliers

Chemical Property of 2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Edit

Chemical Property:

Melting Point:260oC
Boiling Point:747.3°Cat760mmHg
Flash Point:405.8°C
PSA：139.54000
Density:2.17g/cm³
LogP:-1.25970
XLogP3:-0.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:285.08733204
Heavy Atom Count:20
Complexity:367

Purity/Quality:

97% ^*data from raw suppliers

9-A-D-ARABINOFURANOSYL-2-FLUOROADENINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)CO)O)O)F)N

Technology Process of 2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

There total 21 articles about 2-(6-Amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24649-69-2
2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine

: 146-78-1,19768-92-4,21679-14-1,21679-15-2
Fludarabine

Guidance literature:: 2-fluoro-9-(2,3,5-tri-o-benzyl-beta-D-arabinofuranosyl)adenine; With palladium 10% on activated carbon; ammonium formate; In methanol; water; at 25 - 75 ℃; Inert atmosphere;

In water; at 90 - 95 ℃;
DOI:10.1021/op3000509

Reference yield: 93.0%

: 2-fluoro-9-(3,5-di-O-benzoyl-β-D-arabinofuranosyl)adenine

: 146-78-1,19768-92-4,21679-14-1,21679-15-2
Fludarabine

Guidance literature:: With methanol; ammonia; at 0 - 40 ℃; for 6h; Autoclave;
DOI:10.1055/s-0039-1690732

Reference yield: 92.0%

: 3083-77-0
araU

: 146-78-1
2-fluoroadenosine

: 146-78-1,19768-92-4,21679-14-1,21679-15-2
Fludarabine

Guidance literature:: With uridine phosphorylase; disodium hydrogen arsenate heptahydrate; Escherichia coli purine nucleoside phosphorylase; In aq. phosphate buffer; at 52 ℃; pH=7; Enzymatic reaction;
DOI:10.1134/S1068162016040105