1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

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Chemical Name:1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate
CAS No.:1055304-69-2
Molecular Formula:C₄H₄O₄*C₁₇H₁₆FN₃O₂S
Molecular Weight:461.471
Hs Code.:

Synonyms:1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

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Chemical Property of 1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

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Technology Process of 1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

There total 5 articles about 1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 928325-25-1
5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 74-89-5
methylamine

: 1055304-69-2
1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Guidance literature:: 5-(2-fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde; methylamine; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

(2E)-but-2-enedioic acid; In ethanol;
DOI:10.1016/j.bmc.2017.04.014

Reference yield:

: 881673-82-1
5-bromo-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 1055304-69-2
1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In methanol; 1,2-dimethoxyethane; water; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2017.04.014

Reference yield:

: 881676-32-0
5-bromo-1H-pyrrole-3-carboxaldehyde

: 1055304-69-2
1-[5-(2-Fluoropyridin-3-yl)-1-(phenylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 80 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2017.04.014