methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

Base Information

Chemical Name:methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate
CAS No.:233281-63-5
Molecular Formula:C₃₃H₄₂N₄O₉S
Molecular Weight:670.784
Hs Code.:

Synonyms:methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

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Chemical Property of methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

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Technology Process of methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

There total 4 articles about methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 147000-89-3
N-tert-butyloxycarbonylsulfamoyl chloride

: 233281-62-4
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-[(E)-3-cyanocinnamyl]anthranilate

: 233281-63-5
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

Guidance literature:: In pyridine; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(02)00462-5

Reference yield:

: 1882-72-0
methyl 2-amino-5-hydroxybenzoate

: 233281-63-5
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / PPh₃; DEAD / tetrahydrofuran / 96 h / 20 °C

2: 99 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 14 h / 20 °C

3: 99 percent / pyridine / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(02)00462-5

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 233281-63-5
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / PPh₃; DEAD / tetrahydrofuran / 96 h / 20 °C

2: 99 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 14 h / 20 °C

3: 99 percent / pyridine / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(02)00462-5