methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

Base Information

Chemical Name:methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate
CAS No.:540765-38-6
Molecular Formula:C₃₃H₄₄N₄O₉S
Molecular Weight:672.8
Hs Code.:

Synonyms:methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

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Chemical Property of methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

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Technology Process of methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

There total 5 articles about methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 233281-63-5
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[(E)-3-cyanocinnamyl]anthranilate

: 540765-38-6
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

Guidance literature:: With hydrogen; barium sulfate; trimethyleneglycol; In ethanol; at 20 ℃; for 24h; under 760 Torr;
DOI:10.1016/S0968-0896(02)00462-5

Reference yield:

: 1882-72-0
methyl 2-amino-5-hydroxybenzoate

: 540765-38-6
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / PPh₃; DEAD / tetrahydrofuran / 96 h / 20 °C

2: 99 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 14 h / 20 °C

3: 99 percent / pyridine / 1 h / 20 °C

4: 90 percent / H₂ / PdO/BaSO₄ / ethanol / 24 h / 20 °C / 760 Torr

With hydrogen; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; barium sulfate; trimethyleneglycol; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(02)00462-5

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 540765-38-6
methyl 5-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-(tert-butoxycarbonylsulfamoyl)-N-[3-(3-cyanophenyl)propyl]anthranilate

Guidance literature:: Multi-step reaction with 4 steps

1: 41 percent / PPh₃; DEAD / tetrahydrofuran / 96 h / 20 °C

2: 99 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 14 h / 20 °C

3: 99 percent / pyridine / 1 h / 20 °C

4: 90 percent / H₂ / PdO/BaSO₄ / ethanol / 24 h / 20 °C / 760 Torr

With hydrogen; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; barium sulfate; trimethyleneglycol; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(02)00462-5