2-(N-methylanilino)-2-phenylsulfanylacetonitrile

Base Information

• Chemical Name: 2-(N-methylanilino)-2-phenylsulfanylacetonitrile
• CAS No.: 132431-15-3
• Molecular Formula: C₁₅H₁₄N₂S
• Molecular Weight: 254.356
• Mol file: 132431-15-3.mol

Synonyms:2-(N-methylanilino)-2-phenylsulfanylacetonitrile

Chemical Property of 2-(N-methylanilino)-2-phenylsulfanylacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(N-methylanilino)-2-phenylsulfanylacetonitrile

There total 2 articles about 2-(N-methylanilino)-2-phenylsulfanylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(N-methylanilino)acetonitrile (36602-08-1) + diphenyldisulfane (882-33-7) → 2-(N-methylanilino)-2-phenylsulfanylacetonitrile (132431-15-3)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -40 ℃; for 0.75h;

DOI:10.1039/P19940002217

Reference yield:

N-methyl-N-phenylformamide (93-61-8) → 2-(N-methylanilino)-2-phenylsulfanylacetonitrile (132431-15-3)

Guidance literature:

Multi-step reaction with 2 steps

1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,1,3,3-tetramethyldisilazane / acetonitrile / 12 h / 20 °C / Inert atmosphere

2: lithium diisopropyl amide

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,1,3,3-tetramethyldisilazane; lithium diisopropyl amide; In acetonitrile;

DOI:10.1016/j.jcat.2021.01.003

Reference yield: 99.0%

methylmagnesium chloride (676-58-4) + 2-(N-methylanilino)-2-phenylsulfanylacetonitrile (132431-15-3) → 2-(methyl(phenyl)amino)propanenitrile (69905-97-1)

Guidance literature:

With copper(l) iodide; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1039/P19940002217

upstream raw materials:

(N-methylanilino)acetonitrile

diphenyldisulfane

N-methyl-N-phenylformamide

Downstream raw materials:

(E)-2-(N-Methylanilino)-2-hexenenitrile

(E)-7-iodo-2-(N-methylanilino)hept-2-enenitrile

(2E,4E)-2-(Methyl-phenyl-amino)-6-phenylsulfanyl-hexa-2,4-dienenitrile

(2E,4E)-2-(N-methylanilino)-6-phenylsulfanylhexa-2,4-dienenitrile