2,6-DIFLUOROPHENYL ISOCYANATE

Base Information

• Chemical Name: 2,6-DIFLUOROPHENYL ISOCYANATE
• CAS No.: 65295-69-4
• Molecular Formula: C₇H₃F₂NO
• Molecular Weight: 155.104
• Hs Code.: 29291090
• Mol file: 65295-69-4.mol

Synonyms:1,3-Difluoro-2-isocyanatobenzene;2,6-Difluoro-1-isocyanato-benzene;2,6-Difluorobenzene isocyanate;2,6-Difluorophenyl isocyanate;

Chemical Property of 2,6-DIFLUOROPHENYL ISOCYANATE

Chemical Property:

• Appearance/Colour: White to light yellow liquid or low melting solid
• Melting Point: 22-25 °C(lit.)
• Refractive Index: n20/D 1.4928(lit.)
• Boiling Point: 174.4 °C at 760 mmHg
• Flash Point: 51.5 °C
• PSA: 29.43000
• Density: 1.24 g/cm³
• LogP: 1.93210
• Storage Temp.: 0-6°C
• Sensitive.: Moisture Sensitive/Lachrymatory

Purity/Quality:

99% ^*data from raw suppliers

2,6-Difluorophenyl isocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 23-26-28-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,6-Difluorophenyl isocyanate may be used in chemical synthesis studies.

Technology Process of 2,6-DIFLUOROPHENYL ISOCYANATE

There total 3 articles about 2,6-DIFLUOROPHENYL ISOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 2,6-difluoroaniline (5509-65-9) → 2,6-difluorophenyl isocyanate (65295-69-4)

Guidance literature:

In ethyl acetate; for 12h; Reflux;

DOI:10.1002/ardp.200900130

Reference yield:

2,6-difluorobenzamide (18063-03-1) → 2,6-difluorophenyl isocyanate (65295-69-4)

Guidance literature:

With oxalyl dichloride; In toluene; for 3h; Reflux;

Reference yield:

oxalyl dichloride (79-37-8) + 2,6-difluorobenzamide (18063-03-1) → 2,6-difluorophenyl isocyanate (65295-69-4)

Guidance literature:

In 1,2-dichloro-ethane; Cooling with ice; Reflux;

DOI:10.3184/030823409X12559709808197

upstream raw materials:

oxalyl dichloride

2,6-difluorobenzamide

bis(trichloromethyl) carbonate

2,6-difluoroaniline

Downstream raw materials:

C₂₆H₃₄F₂N₄O₂

C₂₆H₃₄F₂N₄O₂

1-(2,6-difluorophenyl)-3-(4-((4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methoxy)phenyl)urea

1-(2,6-difluorophenyl)-3-(4-(4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)phenyl)urea

Refernces

• 1、 Sun, Haiyang,Li, Hui,Wang, Jiayi,Song, Gonghua. "Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin". . p. 977 - 980. Retrieved 2017/11/16.