1303607-07-9

Basic information

• Product Name: MI-773
• Synonyms: MI-773;(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxospiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide;(2'R,3S,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-N-((1r,4R)-4-hydroxycyclohexyl)-2'-neop
• CAS NO: 1303607-07-9
• Molecular Formula: C₂₉H₃₄Cl₂FN₃O₃
• Molecular Weight: 562.5029632
• Mol File: 1303607-07-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 732.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 12.03±0.70(Predicted)
• CAS DataBase Reference: MI-773(CAS DataBase Reference)
• NIST Chemistry Reference: MI-773(1303607-07-9)
• EPA Substance Registry System: MI-773(1303607-07-9)

Safety Data

• Hazardous Substances Data: 1303607-07-9(Hazardous Substances Data)

Usage

Uses

MI-773 is an inhibitor of MDM2-p53 protein-protein interaction (MDM2 inhibitors), currently investigated in clinical trials for cancer treatment.

Upstream product

• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 
• 1303609-36-0 C₄₃H₄₆Cl₂FN₃O₄ 
• 897365-81-0 (3S,3'S,4'R,6'R,8'S,8a'R)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl-3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione 
• 897365-76-3 (3E/Z)-6-chloro-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydro-2H-indol-2-one 
• 74444-81-8 5-chloro-1,3-dihydro-2H-inden-2-one 

Downstream Products

• 1303609-37-1 (2'R,3S,4'S,5R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-(trans-4-hydroxycyclohexyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide trifluoroacetate 

Relevant articles and documents

SPIRO-OXINDOLE MDM2 ANTAGONISTS

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as