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Phorbol 12-myristate 13-acetate

Base Information Edit
  • Chemical Name:Phorbol 12-myristate 13-acetate
  • CAS No.:16561-29-8
  • Deprecated CAS:11016-13-0,11019-85-5,20839-11-6,26894-58-6,27534-73-2,51898-14-7
  • Molecular Formula:C36H56 O8
  • Molecular Weight:616.836
  • Hs Code.:29153900
  • European Community (EC) Number:605-413-5
  • NSC Number:626496,262644
  • UN Number:2811
  • UNII:NI40JAQ945
  • DSSTox Substance ID:DTXSID5023798
  • Nikkaji Number:J4.078I
  • Wikipedia:12-O-Tetradecanoylphorbol-13-acetate
  • Wikidata:Q416716
  • NCI Thesaurus Code:C866
  • Pharos Ligand ID:RKDKAMM28NUC
  • Metabolomics Workbench ID:28630
  • ChEMBL ID:CHEMBL279115
  • Mol file:16561-29-8.mol
Phorbol 12-myristate 13-acetate

Synonyms:12 Myristoyl 13 acetylphorbol;12 O Tetradecanoyl Phorbol 13 Acetate;12-Myristoyl-13-acetylphorbol;12-O-Tetradecanoyl Phorbol 13-Acetate;13-Acetate, 12-O-Tetradecanoyl Phorbol;Acetate, Phorbol Myristate;Acetate, Tetradecanoylphorbol;Myristate Acetate, Phorbol;Phorbol 13-Acetate, 12-O-Tetradecanoyl;Phorbol Myristate Acetate;Tetradecanoylphorbol Acetate;Tetradecanoylphorbol Acetate, 4a alpha Isomer;Tetradecanoylphorbol Acetate, 4a alpha-Isomer

Suppliers and Price of Phorbol 12-myristate 13-acetate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Tetradecanoyl Phorbol Acetate
  • 1mg
  • $ 179.00
  • TRC
  • 4β-Phorbol12-Myristate13-Acetate
  • 5mg
  • $ 200.00
  • TRC
  • 4β-Phorbol12-Myristate13-Acetate
  • 1mg
  • $ 60.00
  • Tocris
  • Phorbol-12-myristate-13-acetate ≥99%(HPLC)
  • 1
  • $ 85.00
  • Tocris
  • Phorbol-12-myristate-13-acetate ≥99%(HPLC)
  • 5
  • $ 282.00
  • Sigma-Aldrich
  • Phorbol 12-myristate 13-acetate synthetic, ≥98.0% (TLC)
  • 25mg
  • $ 1010.00
  • Sigma-Aldrich
  • PMA for use in molecular biology applications, ≥99% (HPLC)
  • 25mg
  • $ 979.00
  • Sigma-Aldrich
  • Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder
  • 25mg
  • $ 890.00
  • Sigma-Aldrich
  • PMA for use in molecular biology applications, ≥99% (HPLC)
  • 10mg
  • $ 621.00
  • Sigma-Aldrich
  • Phorbol-12-myristate-13-acetate
  • 25mg
  • $ 585.52
Total 91 raw suppliers
Chemical Property of Phorbol 12-myristate 13-acetate Edit
Chemical Property:
  • Appearance/Colour:White to off-white solid. 
  • Vapor Pressure:1.55E-22mmHg at 25°C 
  • Refractive Index:1.553 
  • Boiling Point:698.1 °C at 760 mmHg 
  • PKA:11.19±0.70(Predicted) 
  • Flash Point:208.1 °C 
  • PSA:130.36000 
  • Density:1.17 g/cm3 
  • LogP:5.75290 
  • Storage Temp.:−20°C 
  • Sensitive.:Light Sensitive 
  • Solubility.:DMSO: DMSO solutions can be stored dark at −20?#x00b0;C fo 
  • Water Solubility.:Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble  
  • XLogP3:6.5
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:17
  • Exact Mass:616.39751874
  • Heavy Atom Count:44
  • Complexity:1150
  • Transport DOT Label:Poison
Purity/Quality:

95%-98% *data from raw suppliers

Tetradecanoyl Phorbol Acetate *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 38-36/37/38 
  • Safety Statements: 36/37-26 
MSDS Files:

SDS file from LookChem

Useful:
  • Chemical Classes:Other Uses -> Biochemical Research
  • Canonical SMILES:CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
  • Isomeric SMILES:CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
  • Recent ClinicalTrials:Helping Stroke Patients With ThermoSuit Cooling
  • Description Phorbol 12-myristate-13-acetate (16561-29-8) activates protein kinase C (10-100 ng/ml)1. May display PKC-independent effects in various cell types2. Warning: Phorbol 12-myristate-13-acetate is a skin irritant. Avoid contact with this compound.
  • Uses 4β-Phorbol 12-Myristate 13-Acetate is used in the activation of certain pyruvate kinases as well as protein kinases.
Technology Process of Phorbol 12-myristate 13-acetate

There total 5 articles about Phorbol 12-myristate 13-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 2 steps
1: Py
2: (i) NaOMe, MeOH, dioxane, (ii) /BRN= 385737/, Py, (iii) aq. HClO4, MeOH
With pyridine;
DOI:10.1515/znb-1968-0422
Guidance literature:
Multi-step reaction with 2 steps
1: (i) NaOMe, MeOH, dioxane, (ii) /BRN= 397363/, Py
2: (i) Py, (ii) AcOH, (heating)
DOI:10.1515/znb-1968-0422
Guidance literature:
Multistep reaction; (i) NaOMe, MeOH, dioxane, (ii) /BRN= 385737/, Py, (iii) aq. HClO4, MeOH;
DOI:10.1515/znb-1968-0422
Refernces Edit
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