2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol

Base Information

• Chemical Name: 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol
• CAS No.: 181725-52-0
• Molecular Formula: C₃₄H₄₀N₂O₅
• Molecular Weight: 556.702
• Mol file: 181725-52-0.mol

Synonyms:2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol

Chemical Property of 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol

There total 7 articles about 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-Benzyl-N-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-hydroxy-ethoxy)-acetamide (181725-50-8) → 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol (181725-52-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 16h; Heating;

DOI:10.1055/s-1996-4319

Reference yield:

bis(2-aminophenyl)ether (24878-25-9) → 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol (181725-52-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

2: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

3: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

4: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

Reference yield:

bis(2-nitrophenyl)ether (2217-65-4) → 2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethanol (181725-52-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / NH₂NH₂*H₂O / 10percent Pd/C / ethanol / 1 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

3: 1.) NaH / 1.) THF, reflux, 2 h, 2.) THF, 16 h

4: 48 percent / H₂ / 10percent Pd/C / ethanol / 16 h / Ambient temperature

5: 56 percent / LiAlH₄ / tetrahydrofuran / 16 h / Heating

With lithium aluminium tetrahydride; hydrogen; sodium hydride; hydrazine hydrate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1055/s-1996-4319

upstream raw materials:

N-Benzyl-N-[2-(2-{benzyl-[2-(2-hydroxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-hydroxy-ethoxy)-acetamide

bis(2-nitrophenyl)ether

bis(2-aminophenyl)ether

ortho-nitrofluorobenzene

Downstream raw materials:

2-{2-[2-(Benzyl-{2-[2-(benzyl-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethyl}-amino)-phenoxy]-phenyl}-amino)-ethoxy]-ethoxy}-N-{2-[2-(2-methoxy-acetylamino)-phenoxy]-phenyl}-acetamide

N-{2-[2-(2-Methoxy-acetylamino)-phenoxy]-phenyl}-2-(2-{2-[2-(2-{2-[2-({2-[2-(2-methoxy-acetylamino)-phenoxy]-phenylcarbamoyl}-methoxy)-ethoxy]-ethylamino}-phenoxy)-phenylamino]-ethoxy}-ethoxy)-acetamide

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-carboxymethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetic acid

[2-(2-{Benzyl-[2-(2-{benzyl-[2-(2-chlorocarbonylmethoxy-ethoxy)-ethyl]-amino}-phenoxy)-phenyl]-amino}-ethoxy)-ethoxy]-acetyl chloride