diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate

Base Information

• Chemical Name: diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate
• CAS No.: 1198184-26-7
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 1198184-26-7.mol

Synonyms:diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property of diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate

There total 6 articles about diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-methyl-benzaldehyde (104-87-0) + ethyl acetoacetate (141-97-9) → diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate (1198184-26-7)

Guidance literature:

With ammonium acetate; oxygen; at 20 ℃; for 72h; Neat (no solvent);

DOI:10.1039/b906358g

Reference yield:

ammonium acetate (631-61-8,92206-38-7) + ethyl acetoacetate (141-97-9) + 4-methoxy-benzaldehyde (123-11-5) → diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate (1198184-26-7) + C20H23NO5 + diethyl 4-(4-methoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (5448-05-5) + C20H25NO4 + C20H25NO5 + diethyl 1,4-dihydro-2,6-dimethyl-4-(4-methoxyphenyl)pyridine-3,5-dicarboxylate (34014-60-3)

Guidance literature:

With dihydrogen peroxide; 3Mo⁽⁶⁺⁾*3CH₄O*6O^(2-)*C₃₀H₂₀N₆O₆^(6-); In water; at 30 ℃; for 1h; Solvent; Temperature; Reflux;

DOI:10.1016/j.poly.2020.114617

Reference yield:

ammonium acetate (631-61-8,92206-38-7) + ethyl acetoacetate (141-97-9) + 4-chlorobenzaldehyde (104-88-1) → diethyl 2-(4-methylphenyl)-4,6-dimethylpyridine-3,5-dicarboxylate (1198184-26-7) + diethyl 2-(4-chlorophenyl)-4,6-dimethylpyridine-3,5-dicarboxylate + diethyl 4-(4-chlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate (4350-45-2) + 4-(4-chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (35929-79-4) + C20H25NO4 + C19H22ClNO4

Guidance literature:

With dihydrogen peroxide; 3Mo⁽⁶⁺⁾*3CH₄O*6O^(2-)*C₃₀H₂₀N₆O₆^(6-); In water; at 30 ℃; for 1h; Solvent; Temperature; Reflux;

DOI:10.1016/j.poly.2020.114617

upstream raw materials:

4-methyl-benzaldehyde

ethyl acetoacetate

ammonium acetate

4-methoxy-benzaldehyde