[3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester

Base Information

• Chemical Name: [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester
• CAS No.: 117601-28-2
• Molecular Formula: C₂₁H₂₂N₂O₃S
• Molecular Weight: 382.483
• Mol file: 117601-28-2.mol

Synonyms:[3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester

Chemical Property of [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester

There total 4 articles about [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloroacetic acid ethyl ester (105-39-5) + 4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (117601-23-7) → [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester (117601-28-2)

Guidance literature:

With TEA; In ethanol; for 0.75h; Heating;

Reference yield:

E-2-(4-methoxybenzylidene)cyclohexanone (5765-29-7,37722-53-5) → [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester (117601-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / CH₃ONa / methanol / 48 h / 50 °C

2: 86 percent / TEA / ethanol / 0.75 h / Heating

With TEA; sodium methylate; In methanol; ethanol;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → [3-Cyano-4-(4-methoxy-phenyl)-5,6,7,8-tetrahydro-quinolin-2-ylsulfanyl]-acetic acid ethyl ester (117601-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol

2: tetraphosphorus decasulfide / toluene / 4 h / Reflux

3: sodium acetate / ethanol / 4 h / Reflux

With tetraphosphorus decasulfide; ammonium acetate; sodium acetate; In ethanol; toluene;

DOI:10.1002/jhet.3046

upstream raw materials:

chloroacetic acid ethyl ester

4-(4-methoxyphenyl)-2-sulfanylidene-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

E-2-(4-methoxybenzylidene)cyclohexanone

cyclohexanone

Downstream raw materials:

4-(p-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-3(2H)-one

3-amino-4-(p-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline

3-amino-4-(p-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxylic acid