2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

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Chemical Name:2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester
CAS No.:410095-23-7
Molecular Formula:C₃₆H₄₆O₆Si
Molecular Weight:602.843
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

There total 4 articles about 2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3282-30-2
pivaloyl chloride

: 410095-17-9
(2S,3R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-yne-1,2-diol

: 410095-23-7
2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

Guidance literature:: With Er₃N; In dichloromethane;
DOI:10.1016/S0040-4039(01)02120-7

Reference yield:

: 88159-06-2
tert-butyl(diphenyl)(2-propynyloxy)silane

: 410095-23-7
2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / n-BuLi; BF₃*OEt₂ / tetrahydrofuran / -78 °C

2: KHMDS / dimethylformamide / 0 °C

3: 1,2-propanethiol; BF₃*Et₂O / -78 °C

4: 93 percent / Er₃N / CH₂Cl₂

With n-butyllithium; Er₃N; 1,2-propanedithiol; boron trifluoride diethyl etherate; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)02120-7

Reference yield:

: 410095-16-8
(R)-5-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-3-yn-1-ol

: 410095-23-7
2,2-Dimethyl-propionic acid (2S,3R)-7-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-3-(4-methoxy-benzyloxy)-hept-5-ynyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: KHMDS / dimethylformamide / 0 °C

2: 1,2-propanethiol; BF₃*Et₂O / -78 °C

3: 93 percent / Er₃N / CH₂Cl₂

With Er₃N; 1,2-propanedithiol; boron trifluoride diethyl etherate; potassium hexamethylsilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)02120-7