(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

Base Information

• Chemical Name: (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone
• CAS No.: 1312942-00-9
• Molecular Formula: C₁₄H₇BrFN₃O₃
• Molecular Weight: 364.13
• Mol file: 1312942-00-9.mol

Synonyms:(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

Chemical Property of (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

There total 4 articles about (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-fluoro-3-nitro-benzoic acid (317-46-4) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone (1312942-00-9)

Guidance literature:

2-fluoro-3-nitro-benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

5-bromo-1H-pyrrolo[2,3-b]pyridine; With aluminum (III) chloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2020.112963

Reference yield:

2-fluoro-3-nitro-benzoyl chloride (1214341-16-8) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone (1312942-00-9)

Guidance literature:

With aluminum (III) chloride; In nitromethane; at 45 ℃; for 6h;

Reference yield:

2-fluoro-3-nitro-benzoic acid (317-46-4) → (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone (1312942-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 80 °C

2: aluminum (III) chloride / nitromethane / 6 h / 45 °C

With aluminum (III) chloride; thionyl chloride; N,N-dimethyl-formamide; In nitromethane;

upstream raw materials:

2-fluoro-3-nitro-benzoyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

2-fluoro-3-nitro-benzoic acid

2-fluoro-3-nitrobenzaldehyde

Downstream raw materials:

(3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide

2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide