(3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

Base Information

• Chemical Name: (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone
• CAS No.: 1254567-33-3
• Molecular Formula: C₁₄H₉BrFN₃O
• Molecular Weight: 334.147
• Mol file: 1254567-33-3.mol

Synonyms:(3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

Chemical Property of (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone

There total 6 articles about (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone (1312942-00-9) → (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone (1254567-33-3)

Guidance literature:

With tin(II) chloride dihdyrate; In tetrahydrofuran; ethyl acetate; at 60 ℃;

DOI:10.1016/j.ejmech.2020.112963

Reference yield:

2-fluoro-3-nitro-benzoic acid (317-46-4) → (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone (1254567-33-3)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 80 °C

2: aluminum (III) chloride / nitromethane / 6 h / 45 °C

3: tin(II) chloride dihdyrate / ethyl acetate; tetrahydrofuran / 72 h / 60 °C

With aluminum (III) chloride; thionyl chloride; tin(II) chloride dihdyrate; N,N-dimethyl-formamide; In tetrahydrofuran; nitromethane; ethyl acetate;

Reference yield:

2-fluoro-3-nitrobenzaldehyde (96516-29-9) → (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone (1254567-33-3)

Guidance literature:

Multi-step reaction with 4 steps

1: water; aminosulfonic acid; sodium chlorite / 1,4-dioxane / 0.5 h / 20 °C

2: thionyl chloride / N,N-dimethyl-formamide / 80 °C

3: aluminum (III) chloride / nitromethane / 6 h / 45 °C

4: tin(II) chloride dihdyrate / ethyl acetate; tetrahydrofuran / 72 h / 60 °C

With aluminum (III) chloride; sodium chlorite; thionyl chloride; tin(II) chloride dihdyrate; aminosulfonic acid; water; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; nitromethane; ethyl acetate;

upstream raw materials:

2-fluoro-3-nitro-benzoic acid

2-fluoro-3-nitrobenzaldehyde

2-fluoro-3-nitro-benzoyl chloride

(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone

Downstream raw materials:

(3-amino-2-fluoro-phenyl)-(5-cyano-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone

2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide

N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide