α-(trichloromethyl)cyclohexanemethanol

Base Information

• Chemical Name: α-(trichloromethyl)cyclohexanemethanol
• CAS No.: 57741-12-5
• Molecular Formula: C₈H₁₃Cl₃O
• Molecular Weight: 231.55
• Mol file: 57741-12-5.mol

Synonyms:α-(trichloromethyl)cyclohexanemethanol

Chemical Property of α-(trichloromethyl)cyclohexanemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-(trichloromethyl)cyclohexanemethanol

There total 13 articles about α-(trichloromethyl)cyclohexanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

chloroform (67-66-3,8013-54-5) + cyclohexanecarbaldehyde (2043-61-0) → α-(trichloromethyl)cyclohexanemethanol (57741-12-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 7h;

DOI:10.1021/jo000584n

Reference yield: 94.0%

cyclohexanecarbaldehyde (2043-61-0) + trichloroacetic acid (76-03-9) → α-(trichloromethyl)cyclohexanemethanol (57741-12-5)

Guidance literature:

With sodium trichloroacetate; In N,N-dimethyl-formamide; at 25 - 35 ℃;

DOI:10.1021/jo9916582

Reference yield: 94.0%

trimethyl(2,2,2-trichloro-1-cyclohexylethoxy)silane (57741-18-1) → α-(trichloromethyl)cyclohexanemethanol (57741-12-5)

Guidance literature:

trimethyl(2,2,2-trichloro-1-cyclohexylethoxy)silane; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; at 20 ℃; for 0.166667h;

With potassium carbonate; In tetrahydrofuran; 2-methyltetrahydrofuran; water; for 0.5h;

DOI:10.1021/jo3001063

upstream raw materials:

chloral

cyclohexylmagnesium bromide

2,2,2-trichloro-1-(cyclohex-2-enyl)ethanol

chloroform

Downstream raw materials:

trimethyl(2,2,2-trichloro-1-cyclohexylethoxy)silane

1,1,1-trichloro(cyclohexyl)ethan-2-one

2-cyclohexyl-2-hydroxyacetic acid

cyclohexanecarbaldehyde