4-Hydrazinobenzenesulfonic acid

Base Information

• Chemical Name: 4-Hydrazinobenzenesulfonic acid
• CAS No.: 98-71-5
• Deprecated CAS: 1171310-21-6
• Molecular Formula: C6H8 N2 O3 S
• Molecular Weight: 188.207
• Hs Code.: 29280000
• European Community (EC) Number: 202-694-2,639-341-0
• NSC Number: 1608
• UNII: F3J225IK1D
• DSSTox Substance ID: DTXSID9059177
• Nikkaji Number: J41.354B
• Wikidata: Q27277588
• ChEMBL ID: CHEMBL510966
• Mol file: 98-71-5.mol

Synonyms:4-Hydrazinobenzenesulfonic acid;98-71-5;4-hydrazinylbenzenesulfonic acid;Phenylhydrazine-4-sulfonic acid;Benzenesulfonic acid, 4-hydrazino-;p-Sulfophenylhydrazine;4-Hydrazinobenzenesulphonic acid;4-Sulfophenylhydrazine;Phenylhydrazinesulfonic acid;p-Hydrazinobenzenesulfonic acid;Phenylhydrazine-p-sulfonic acid;Sulfanilic acid, N-amino-;p-Hydrazinophenylsulfonic acid;854689-07-9;Benzenesulfonic acid, p-hydrazino-;NSC 1608;EINECS 202-694-2;BRN 0514779;UNII-F3J225IK1D;AI3-09050;F3J225IK1D;NSC-1608;Benzenesulfonic acid, 4-hydrazinyl-;3-15-00-00865 (Beilstein Handbook Reference);MFCD00025097;4-hydrazinylbenzene-1-sulfonic acid;p-Sulfo-phenylhydrazin;p-sulfophenyl hydrazine;4-hydrazinobenzensulfonsyre;SCHEMBL34520;p-Phenylhydrazinesulfonic acid;4-hydrazinylbenzenesulfonicacid;CHEMBL510966;p-hydrazino-benzenesulfonic acid;4-hydrazino-benzenesulfonic acid;DTXSID9059177;NSC1608;STR07041;benzene;hydrazine;hydrogen sulfite;BBL008614;MFCD00480958;STK396700;AKOS001590303;Hydrazinobenzenesulfonic acidhemihydrate;CS-W016811;PHENYLHYDRAZINE-P-SULFOMNIC ACID;NCGC00325751-01;AC-18236;BP-30245;LS-31965;Phenylhydrazine-4-sulfonic acid hemihydrate;4-HYDRAZINOBENZENESULFONIC ACID [MI];FT-0631512;H0176;H1662;AB00087113-01;AB00087113-03;A845897;W-100068;Q27277588;F0266-1028

Chemical Property of 4-Hydrazinobenzenesulfonic acid

Chemical Property:

• Appearance/Colour: yellow powder
• Melting Point: Decomposes
• Refractive Index: 1.6490 (estimate)
• Boiling Point: °Cat760mmHg
• PKA: -0.66±0.50(Predicted)
• Flash Point: °C
• PSA: 100.80000
• Density: 1.583g/cm³
• LogP: 2.07300
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Sensitive.: Hygroscopic
• Solubility.: DMSO (Slightly), Water (Slightly)
• Water Solubility.: It is soluble in water.
• XLogP3: -2.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 188.02556330
• Heavy Atom Count: 12
• Complexity: 226

Purity/Quality:

99% ^*data from raw suppliers

Phenylhydrazine-4-sulfonic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-60-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NN)S(=O)(=O)O
• Uses: Hemihydrate of 4-Hydrazinobenzenesulfonic Acid is used in analytical experiments to determine trace components of mixtures. Also used in the synthesis of inhibitors of coxsackievirus B3 replication. T artrazine (T007700) analog. 4-Hydrazinobenzenesulfonic Acid is used as an intermediate to manufacture pharmaceuticals, dyes and other organic synthesis. They have active applications in organic synthesis for agrochemicals, pharmaceuticals, photographic, heat stabilizers, polymerization catalysts, flame-retardants, blowing agents for plastics, explosives, and dyes.

Technology Process of 4-Hydrazinobenzenesulfonic acid

There total 26 articles about 4-Hydrazinobenzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-sulfobenzenediazonium (2154-66-7,4332-41-6) → 4-hydrazino-benzenesulfonic acid (98-71-5)

Guidance literature:

4-sulfobenzenediazonium; With sodium sulphite-heptahydrate; In water; at 0 - 5 ℃; for 2h;

With hydrogenchloride; In water; for 0.5h;

DOI:10.1016/j.molstruc.2018.07.081

Reference yield: 85.0%

4-Sulfo-benzenediazonium; hydrogen sulfate → 4-hydrazino-benzenesulfonic acid (98-71-5)

Guidance literature:

4-Sulfo-benzenediazonium; hydrogen sulfate; With sodium sulfite; In water; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

phenylhydrazine (100-63-0) → 4-hydrazino-benzenesulfonic acid (98-71-5)

Guidance literature:

With sulfuric acid; at 80 - 100 ℃;

upstream raw materials:

4-diazobenzenesulfonic acid

4-nitroamino-benzenesulfonic acid

ethanol

acetic acid

Downstream raw materials:

4-[N'-(α-hydroxy-3-nitro-benzyl)-hydrazino]-benzenesulfonic acid

4-Nitro-benzaldehyd-<4-sulfo-phenylhydrazon>

4-[N'-(α-hydroxy-benzyl)-hydrazino]-benzenesulfonic acid

4-[N'-(2,α-dihydroxy-benzyl)-hydrazino]-benzenesulfonic acid

Refernces

• 1、 Khan, Shakeel Ahmad,Shahid, Sammia,Kanwal, Sadia,Hussain, Ghulam. "Synthesis characterization and antibacterial activity of Cr (III), Co (III), Fe (II), Cu (II), Ni (III) complexes of 4-(2-(((2-hydroxy-5-nitrophenyl) diazenyl) (phenyl) methylene) hydrazinyl) benzene sulfonic acid based formazan dyes and their applications on leather". . p. 31 - 43. Retrieved 2018.
• 2、 Khan, Shakeel Ahmad,Shahid, Sammia,Kanwal, Sadia,Rizwan, Komal,Mahmood, Tariq,Ayub, Khurshid. "Synthesis of novel metal complexes of 2-((phenyl (2-(4-sulfophenyl) hydrazono) methyl) diazenyl) benzoic acid formazan dyes: Characterization, antimicrobial and optical properties studies on leather". . p. 73 - 89. Retrieved 2018/09/18.