4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one

Base Information

• Chemical Name: 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one
• CAS No.: 1345700-39-1
• Molecular Formula: C₁₈H₁₇N₃O₃
• Molecular Weight: 323.351
• Mol file: 1345700-39-1.mol

Synonyms:4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one

Chemical Property of 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one

There total 4 articles about 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethylene dibromide (106-93-4) + 2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (215191-49-4) → 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one (1345700-39-1)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; at 80 ℃; for 10.5h;

DOI:10.3987/COM-11-12299

Reference yield: 51.0%

1,2-dichloro-ethane (107-06-2,52399-93-6) + 2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one (215191-49-4) → 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one (1345700-39-1)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; at 80 ℃; for 9h;

DOI:10.3987/COM-11-12299

Reference yield:

2-benzoylamino-3-chloropropenoic acid (99074-27-8) → 4'-(2-hydroxyethyl)-2-phenyl-1'H,5H-spiro[oxazole-4,2'-quinoxalin]-3'(4'H)-one (1345700-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol / 6.5 h / Reflux

2: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 9 h / 80 °C

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; In ethanol; acetonitrile;

DOI:10.3987/COM-11-12299

upstream raw materials:

2-benzoylamino-3-chloropropenoic acid

1,2-dichloro-ethane

2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one

ethylene dibromide

Downstream raw materials:

1-(2-hydroxyethyl)-3-methylquinoxalin-2(1H)-one

benzamide