Tripelennamine

Base Information

Chemical Name:Tripelennamine
CAS No.:91-81-6
Molecular Formula:C16H21 N3
Molecular Weight:255.363
Hs Code.:
European Community (EC) Number:202-100-1
NSC Number:118946
UNII:3C5ORO99TY
DSSTox Substance ID:DTXSID8023717
Nikkaji Number:J4.349D
Wikipedia:Tripelennamine
Wikidata:Q415203
NCI Thesaurus Code:C61991
RXCUI:10847
Pharos Ligand ID:YG5JXS4DGCJ9
Metabolomics Workbench ID:43084
ChEMBL ID:CHEMBL1241
Mol file:91-81-6.mol

Synonyms:Azaron;Histantin;Pyribenzamine;Tripelennamine;Tripelennamine Citrate;Tripelennamine Citrate (1:1);Tripelennamine Hydrochloride;Tripelennamine Maleate;Tripelennamine Maleate (1:1);Tripelennamine Monohydrochloride;Vetibenzamin

Suppliers and Price of Tripelennamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
Tripelennamine
25 mg
$ 375.00

Biosynth Carbosynth
Tripelennamine
10 mg
$ 225.00

Biosynth Carbosynth
Tripelennamine
5 mg
$ 150.00

Biosynth Carbosynth
Tripelennamine
2 mg
$ 70.00

American Custom Chemicals Corporation
TRIPELENNAMINE 95.00%
5MG
$ 496.61

AK Scientific
Tripelennamine
25mg
$ 556.00

AK Scientific
Tripelennamine
2mg
$ 144.00

Total 30 raw suppliers

Chemical Property of Tripelennamine

Chemical Property:

Appearance/Colour:oily liquid
Melting Point:25°C
Refractive Index:nD25 1.5759-1.5765
Boiling Point:185 - 190 C at 1.7 mm Hg
PKA:pKa 3.90±0.08(H2O t undefined I = 0.30 (NaCl)) (Uncertain);8.68±0.06(H2O t undefined I = 0.30 (NaCl)) (Uncertain)
PSA：19.37000
Density:1.0683 (rough estimate)
LogP:2.64980
Water Solubility.:587.3mg/L(30 oC)
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:255.173547683
Heavy Atom Count:19
Complexity:236

Purity/Quality:

99% ^*data from raw suppliers

Tripelennamine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Toxic by ingestion.
Hazard Codes:Toxic by ingestion.

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2
Uses Medicine (antihistamine, sunburn treatment). This drug lessens the allergic response of the organism caused by histamine. Tripelennamine is used for allergic symptoms, rhinitis, conjunctivitis, and for allergic and anaphylactic reactions. Synonyms of this drug are pelanin and pyribenzamine.
Therapeutic Function Antihistaminic

Technology Process of Tripelennamine

There total 7 articles about Tripelennamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 872298-31-2
2-(N-benzyl-pyridin-2-yl-amino)ethanol

: 124-40-3
dimethyl amine

: 91-81-6
tripelennamine

Guidance literature:: With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 20 ℃; Inert atmosphere; Reflux;

Reference yield: 74.0%

: 874493-33-1
pyridin-2-yl N,N,N',N'-tetramethyldiamidophosphate

: 103-55-9
N,N-dimethyl-N'-benzyl-1,2-ethanediamine

: 91-81-6
tripelennamine

Guidance literature:: With TurboGrignard; In tetrahydrofuran; at 0 - 25 ℃; for 8h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b03698

Reference yield: 49.0%

: N-benzyl-N-(2-(dimethylamino)ethyl)pyridine-2-sulfonamide

: 91-81-6
tripelennamine

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triphenylborane; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 60 ℃; for 16h; Glovebox; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.joc.0c00009