103-55-9

Basic information

• Product Name: N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE
• Synonyms: n,n-dimethyl-n’-(phenylmethyl)-2-ethanediamine;N,N-Dimethyl-N'-benzylethylenediamine;N-Benzyl-N,N-dimethylenediamine;N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE;N'-BENZYL-N,N-DIMETHYLETYLENEDIAMINE;2-benzylaminoethyldimethylamine;N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE, 9 5%;N-[2-(Dimethylamino)ethyl]benzenemethanamine
• CAS NO: 103-55-9
• Molecular Formula: C₁₁H₁₈N₂
• Molecular Weight: 178.27
• EINECS: 203-122-4
• Product Categories: Nitrogen Compounds;Organic Building Blocks;Polyamines
• Mol File: 103-55-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 122-124 °C11 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 0.922 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.509(lit.)
• PKA: 9.35±0.19(Predicted)
• BRN: 2641339
• CAS DataBase Reference: N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE(103-55-9)
• EPA Substance Registry System: N'-BENZYL-N,N-DIMETHYLETHYLENEDIAMINE(103-55-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 103-55-9(Hazardous Substances Data)

Usage

Chemical Properties

Clear pale yellow liquid

Uses

N′-Benzyl-N,N-dimethylethylenediamine may be used in chemical synthesis studies.

Upstream product

• 1485-70-7 N-benzylbenzamide 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 100-52-7 benzaldehyde 
• 108-00-9 N,N-dimethylethylenediamine 
• 931-89-5 (E)-cyclooctene 
• 127141-10-0 3-((2-(Dimethylamino)ethyl)benzylamino)propionic acid 
• 23956-51-6 N¹-benzylidene-N²,N²-dimethylethane-1,2-diamine 
• 100-46-9 benzylamine 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 65894-26-0 N-benzyl-2-bromoethylamine 
• 124-40-3 dimethyl amine 
• 127141-09-7 Methyl 3-((2-(dimethylamino)ethyl)benzylamino)propionate 
• 2862-39-7 2-(dimethylamino)ethyl bromide hydrobromide 

Downstream Products

• 101117-32-2 N-benzyl-N',N'-dimethyl-N-thiazol-2-yl-ethylenediamine 
• 531-08-8 RP 2971 
• 116028-84-3 N'-benzyl-N,N-dimethyl-N'-(4-methyl-pyrimidin-2-yl)-ethane-1,2-diamine 
• 110530-75-1 acetoxy-phenyl-acetic acid-[benzyl-(2-dimethylamino-ethyl)-amide] 
• 127141-09-7 Methyl 3-((2-(dimethylamino)ethyl)benzylamino)propionate 
• 60138-71-8 2,4-bis(dimethylamino)-3-cyanopyridine 
• 1026078-06-7 N-benzyl-N-(2-dimethylamino-ethyl)-2-(4-formyl-naphthalen-1-yl)-acetamide 

Relevant articles and documents

CLEAVABLE TETRAZINE USED IN BIO-ORTHOGONAL DRUG ACTIVATION

Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. The invention includes a kit for releasing a Construct CA bound to a Trigger TR, the kit comprising a tetrazine and a dienophile, wherein the Trigger is the tetrazine. The invention also includes the use of the formation of a pyridazine by reacting a tetrazine comprising a Construct CA bound thereto and a dienophile, as a chemical tool for the release, in a chemical, biological or physiological environment, of said Construct.

Benzenesulfonamide derivatives and their use as MEK inhibitors

Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARBand the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.

Cu(II) CATALIZED HYDROLYSIS OF AN UNACTIVATED ESTER BASED ON REVERSIBLE CONJUGATE ADDITION.

Cu(II) catalysis provides a 16,000-fold acceleration in the hydrolysis of methyl acrylate when a removable vicinal diamine ligand is used to increase the stability of the required copper chelate.