4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene

Base Information

• Chemical Name: 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene
• CAS No.: 337520-54-4
• Molecular Formula: C₁₆H₂₀F₂N₂O₅
• Molecular Weight: 358.342
• Mol file: 337520-54-4.mol

Synonyms:4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene

Chemical Property of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene

There total 2 articles about 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,6-Difluoro-4-nitrophenol (658-07-1) + ethyl acetate (141-78-6) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) + diethylazodicarboxylate (1972-28-7,218603-74-8) → 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene (337520-54-4)

Guidance literature:

With triphenylphosphine; In hexane; dichloromethane;

Reference yield:

3,4,5-trifluoronitrobenzene (66684-58-0) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene (337520-54-4)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 50 ℃; for 16h;

Reference yield: 87.0%

4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoronitrobenzene (337520-54-4) → 4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoroaniline (337520-55-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;

DOI:10.1248/cpb.56.758

upstream raw materials:

2,6-Difluoro-4-nitrophenol

ethyl acetate

t-butyl 4-hydroxy piperidine-1-carboxylate

diethylazodicarboxylate

Downstream raw materials:

4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3,5-difluoroaniline