L-Theanine

Base Information

• Chemical Name: L-Theanine
• CAS No.: 34271-54-0
• Molecular Formula: C7H14N2O3
• Molecular Weight: 174.2
• Hs Code.: 2924199090
• Mol file: 34271-54-0.mol

Synonyms:DL-Glutamine,N-ethyl-;Glutamine, N-ethyl-, DL- (8CI);

Chemical Property of L-Theanine

Chemical Property:

• Appearance/Colour: white or off white powder
• Vapor Pressure: 1.32E-08mmHg at 25°C
• Melting Point: 200 °C
• Refractive Index: 1.492
• Boiling Point: 430.2 °C at 760 mmHg
• PKA: 2.24±0.10(Predicted)
• Flash Point: 214 °C
• PSA: 92.42000
• Density: 1.171 g/cm³
• LogP: 0.40580
• Storage Temp.: 2-8°C
• Solubility.: Water (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

DL-Theanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R43:
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 28-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: L-Theanine, a naturally occurring amino acid found in tea leaves, has several diverse applications in different fields. In the field of health and wellness, it is commonly used as a dietary supplement to promote relaxation and reduce stress and anxiety. Its role as a calming agent is pivotal in improving mood and cognitive function. Additionally, in the food and beverage industry, L-Theanine is utilized as a flavor enhancer, contributing to the umami taste found in certain teas and other products. In the realm of research and pharmaceuticals, it is studied for its potential cognitive-enhancing and neuroprotective effects, making it a subject of interest in the development of drugs for conditions like Alzheimer's disease. Its multifaceted utility underscores its significance in promoting well-being, enhancing flavor, and advancing scientific research, where it plays a crucial role in relaxation, taste enhancement, and cognitive health.

Technology Process of L-Theanine

There total 34 articles about L-Theanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Z-L-theanine (95082-77-2) → N-ethyl-L-glutamine (3081-61-6,5822-62-8,17010-37-6,34271-54-0)

Guidance literature:

With 20% palladium hydroxide-activated charcoal; hydrogen; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1021/acschemneuro.7b00036

Reference yield: 100.0%

ethanamine hydrochloride (557-66-4) + monosodium glutamate (142-47-2) → N-ethyl-L-glutamine (3081-61-6,5822-62-8,17010-37-6,34271-54-0)

Guidance literature:

With D-glucose; 5'-adenosine monophosphate; In phosphate buffer; at 30 ℃; for 48h; pH=7;

DOI:10.1271/bbb.70663

Reference yield: 91.0%

ethylamine (75-04-7,85404-22-4) → N-ethyl-L-glutamine (3081-61-6,5822-62-8,17010-37-6,34271-54-0)

Guidance literature:

L-glutamic acid 5-methyl ester; With triethylamine; acetylacetone; In methanol; at 60 ℃; for 1h;

ethylamine; In methanol; water; for 6h; Product distribution / selectivity;

upstream raw materials:

Z-L-theanine

L-glutamic acid-5-ethyl ester; hydrochloride

ethylamine

L-glutamic acid 5-methyl ester

Downstream raw materials:

L-glutamic acid

ethylamine

Boc-theanine (Boc-Tea-OH)

Refernces

• 1、 Cadimir. "". . p. 462,466. Retrieved 1960.
• 2、 Sebih, Fatiha,Rousset, Matthieu,Bellahouel, Salima,Rolland, Marc,De Jesus Ferreira, Marie Celeste,Guiramand, Janique,Cohen-Solal, Catherine,Barbanel, Gérard,Cens, Thierry,Abouazza, Mohammed,Tassou, Adrien,Gratuze, Maud,Meusnier, Céline,Charnet, Pierre,Vignes, Michel,Rolland, Valérie. "Characterization of l -Theanine Excitatory Actions on Hippocampal Neurons: Toward the Generation of Novel N-Methyl- d -aspartate Receptor Modulators Based on Its Backbone". . p. 1724 - 1734. Retrieved 2017/08/21.
• 3、 Chen, Xingyi,Su, Lingqia,Wu, Dan,Wu, Jing. "Application of recombinant Bacillus subtilis γ-glutamyltranspeptidase to the production of l-theanine". . p. 1429 - 1439. Retrieved 2014/11/07.