methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate
CAS No.:1403381-85-0
Molecular Formula:C₁₉H₁₈BrNO₅
Molecular Weight:420.26
Hs Code.:

Synonyms:methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

There total 6 articles about methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 67-56-1
methanol

: 1403381-84-9
2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-[(trimethylsilyl)oxy]acetonitrile

: 1403381-85-0
methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

Guidance literature:: With acetyl chloride; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 1403381-85-0
methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

2.1: thionyl chloride / 3 h / 85 °C

2.2: 15 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 - 50 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 6 h / 0 - 20 °C / Inert atmosphere

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / Inert atmosphere

5.2: -78 - 20 °C

6.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

7.1: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; thionyl chloride; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; acetyl chloride; zinc(II) iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1403381-82-7
4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepine-7-carbaldehyde

: 1403381-85-0
methyl 2-(4-benzyl-6-bromo-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-7-yl)-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc(II) iodide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: acetyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

With acetyl chloride; zinc(II) iodide; In dichloromethane;