SYNTHESIS OF (13)C- AND (2)H-LABELLED PQQ

Article abstract of DOI:10.1016/S0040-4039(00)82160-7

The scheme developed by Corey and Tramontano <5> for the synthesis of PQQ 7 was adopted to prepare 3-(13)C-PQQ 7a. 3-(2)H-PQQ 7b could be obtained by a modification of this procedure. 8-(2)H-PQQ 7c was prepared by a different approach, applying isatin 5 in a Pfitzinger quinoline synthesis.Merits of this approach for the synthesis of radiolabelled PQQ are discussed.