5-Bromo-N-methoxy-N-methylpicolinamide

Base Information

• Chemical Name: 5-Bromo-N-methoxy-N-methylpicolinamide
• CAS No.: 1211592-38-9
• Molecular Formula: C8H9BrN2O2
• Molecular Weight: 245.076
• Hs Code.: 2933399090
• Mol file: 1211592-38-9.mol

Synonyms:5-Bromo-N-methoxy-N-methylpicolinamide;5-bromo-N-methoxy-N-methyl-2-Pyridinecarboxamide

Chemical Property of 5-Bromo-N-methoxy-N-methylpicolinamide

Chemical Property:

• Boiling Point: 365.8±27.0 °C(Predicted)
• PKA: -0.54±0.10(Predicted)
• PSA: 42.43000
• Density: 1.526±0.06 g/cm3(Predicted)
• LogP: 1.47750
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

5-Bromo-N-methoxy-N-methylpyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-N-methoxy-N-methylpicolinamide

There total 2 articles about 5-Bromo-N-methoxy-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-bromoisonicotinic acid (30766-11-1) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 5-bromo-N-methyoxy-N-methylpyridine-2-carboxamide (1211592-38-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 5 ℃;

Reference yield:

5-bromopyridine-2-carbonyl chloride (137178-88-2) + N,0-dimethylhydroxylamine (1117-97-1) → 5-bromo-N-methyoxy-N-methylpyridine-2-carboxamide (1211592-38-9)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1016/j.bmcl.2010.07.055

Reference yield: 90.0%

5-bromo-N-methyoxy-N-methylpyridine-2-carboxamide (1211592-38-9) + methylmagnesium chloride (676-58-4) → 1-(5-bromopyridin-2-yl)ethanone (214701-49-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

5-bromopyridine-2-carbonyl chloride

N,0-dimethylhydroxylamine

5-bromoisonicotinic acid

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

1-(5-bromopyridin-2-yl)ethanone

[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]boronic acid

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