Sodium propionate

Base Information

• Chemical Name: Sodium propionate
• CAS No.: 137-40-6
• Deprecated CAS: 686-67-9,8027-08-5,1159574-04-5,1159574-05-6,8027-08-5
• Molecular Formula: C3H5NaO2
• Molecular Weight: 96.0613
• Hs Code.: 2915.50
• European Community (EC) Number: 205-290-4,264-460-6
• ICSC Number: 0557
• UNII: DK6Y9P42IN
• DSSTox Substance ID: DTXSID7021996
• Nikkaji Number: J4.430J
• Wikipedia: Sodium_propionate
• Wikidata: Q420130
• NCI Thesaurus Code: C84167
• RXCUI: 1432980
• ChEMBL ID: CHEMBL500826
• Mol file: 137-40-6.mol

Synonyms:Propanoicacid, sodium salt (9CI);Bioban-S;Deketon;Impedex;Mycoban;Napropion;Ocuseptine;Propi-Ophtal;Propiofar;Propion;Propisol;Sodium ethanecarboxylate;Whit-Pro;

Chemical Property of Sodium propionate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 4.23mmHg at 25°C
• Melting Point: 285-286 °C(lit.)
• Boiling Point: 141.7 °C at 760 mmHg
• Flash Point: 57.7 °C
• PSA: 40.13000
• Density: 1.51[at 20℃]
• LogP: -0.85370
• Storage Temp.: Store at RT.
• Sensitive.: Hygroscopic
• Solubility.: H2O: 0.1 g/mL, clear
• Water Solubility.: 995 g/L (20 ºC)
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 96.01872368
• Heavy Atom Count: 6
• Complexity: 44.1

Purity/Quality:

99% ^*data from raw suppliers

Sodium Propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 21-38-36/37/38
• Safety Statements: 36/37-36/37/39-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Organic Acids, Metal Salts
• Canonical SMILES: CCC(=O)[O-].[Na+]
• Recent ClinicalTrials: Impact of Propionic Acid on Regulatory T Cell Function in Children With CKD
• Inhalation Risk: Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.
• description: Sodium propionate is the salt form of propionic acid, which is an organic acid that is produced during the chemical degradation of sugar. It is a compound that is produced naturally in the body when certain fatty acids and amino acids are metabolized. Propionic acid is metabolized by a series of enzymatic reactions that are dependent on the presence of vitamin B-12, according to a 1996 article in the "International Journal of Vitamin and Nutrition Research." Sodium propionate is also chemically manufactured for a variety of industrial uses. Sodium propionate is a common food additive that is industrially manufactured but also occurs in nature. Since it is toxic to mold and some species of bacteria, it is an especially effective additive in baked goods or other products that are susceptible to spoilage. sodium propionate is an effective inhibitor of the growth of certain molds and some bacteria in bakery goods. It is usually preferred in non-yeast leavened bakery products because the calcium ions’ of calcium propionate interfere with the chemical leavening agents. In those bakery products, such as cakes, tortillas, pie fillings etc., chemically leaved agents are used (e.g. baking powder). sodium propionate? is easy to handle and easy to incorporate into flour. It is a safe compound when encountered at the low levels found in food.
• Uses: Primary uses: Antifungal agent, antiseptic agent (topical), disinfectant, food additive, ophthalmic agent. It is used primarily as a mold inhibitor in bakery products. It is approved for use as a food additive in the EU, USA and Australia and New Zealand (where it is listed by its INS number 281). Chemically synthesized sodium propionate is most commonly used as a preservative in the food industry. It prevents the growth of mold and some bacteria, thereby prolonging the shelf life of packaged baked goods. According to the Code of Federal Regulations, sodium propionate is generally recognized as safe when used as a food additive. It is also used to prevent mold growth in packaged and processed cheese products. In addition, ammonium propionate is used as an additive in animal feed to prevent overgrowth of unwanted bacteria in the stomachs of livestock. It can be used as preservatives; used for anti-mould for cakes, waxberry and other mildew It can be used as germicide and antiseptic. Sodium propionate wet acid preservative has its antibacterial effect be affected by the environmental PH. The minimum inhibitory concentration was 0.01% at pH 5.0 and 0.5% at pH 6.5. In acidic medium, it has a strong inhibitory effect against various types of mold, aerobic bacillus or Gram-negative bacteria. It has special effect in prevention the production of aflatoxin while having no effect on the yeast. In addition, it is also used as a food preservative. In the leather, it can be used as masking agent in order to improve the alkali resistance of leather and tanning uniformity. In the food industry, it can be used for pastry preservation with the usage amount of 2.5g/kg (based on propionic acid, the same as below); in 3% to 5% aqueous solution, the maximal amount for soaking waxberry is 50g/kg. It can also be used as feed antiseptic. Germicide, antiseptic. Used for determination of transaminase; The general dosage is 0.1-0.3%. Fungicide, mold preventative. It is used as a food preservative and is represented by the food labeling E number E281 in Europe; it is used primarily as a mold inhibitor in bakery products. It is approved for use as a food additive in the EU, USA and Australia and New Zealand ( where it is listed by its INS number 281 ) . Sodium Propionate is an antimicrobial agent that is the sodium salt of propionic acid. it occurs as colorless, transparent crystals or a gran- ular crystalline powder. it is odorless or has a faint acetic–butyric acid odor, and is deliquescent. it is prepared by neutralizing propionic acid with sodium hydroxide. it is used in baked goods; nonalcoholic beverages; cheeses; confections and frostings; gelatins, puddings, and fillings; jams and jellies; meat products; and soft candy.
• Description: Sodium propanoate or sodium propionate is the sodium salt of propionic acid which has the chemical formula Na(C2H5COO).

Technology Process of Sodium propionate

There total 19 articles about Sodium propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

calcium lactate (814-80-2) → sodium proprionate (137-40-6)

Guidance literature:

With bis(acetylacetonato)dioxidomolybdenum(VI); In water; at 200 - 270 ℃; Inert atmosphere;

DOI:10.1039/c3gc36874b

Reference yield:

propionyl chloride (79-03-8) → sodium proprionate (137-40-6) + sodium pentafluoropropionate (378-77-8)

Guidance literature:

propionyl chloride; With hydrogen fluoride; Electrochemical reaction;

With sodium hydroxide; In water;

DOI:10.1016/j.jfluchem.2010.12.004

Reference yield:

N-tert-butylpropionamide (1118-32-7) → sodium proprionate (137-40-6) + tert-butylamine (75-64-9)

Guidance literature:

With water; sodium hydroxide; In methanol; at 173 - 175 ℃; for 9.5h; under 7500.75 - 11251.1 Torr; Temperature; Pressure; Reagent/catalyst; Inert atmosphere;

upstream raw materials:

sodium 2-propenoate

4-nitrophenyl propionate

Ethyl propionate

carbon dioxide

Downstream raw materials:

N-(Diphenylmethylen)propionamid

3-(3-ethoxy-phenyl)-2-methyl-acrylic acid

benzyl proprionate

3-(4-anisyl)-2-methylacrylic acid

Refernces

• 1、 Yang, Jun,Hong, Kunlun,Bonnesen, Peter V.. "A method for preparing sodium acrylate-d3, a useful and stable precursor for deuterated acrylic monomers". . p. 743 - 748. Retrieved 2011.
• 2、 -. "PROCESS FOR PREPARATION OF TERT-BUTYLAMINE AND PROPIONIC ACID SALTS FROM N-TERTIARY BUTYL ACRYLAMIDE". Page/Page column 16-17. . Retrieved 2021/11/13.