3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride

Base Information

• Chemical Name: 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride
• CAS No.: 66-84-2
• Molecular Formula: C6H13NO5^.HCl
• Molecular Weight: 215.634
• Hs Code.: 2932.99
• European Community (EC) Number: 200-638-1
• NSC Number: 283301
• DSSTox Substance ID: DTXSID60931528
• NCI Thesaurus Code: C83732
• RXCUI: 236608
• Mol file: 66-84-2.mol

Synonyms:3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride;1397188-81-6;Glucosamine hydrochloride;D-Glucosamine-1-13C hydrochloride;D-Galactosamine HCl;2-[15N]amino-2-deoxy-D-galactose hydrochloride;2-Amino-2-deoxy-D-[1-13C]galactose hydrochloride;478518-54-6;14257-79-5;SCHEMBL15541837;DTXSID60931528;CCG-2258;.beta.-D-Galaltosamine hydrochloride;C(O)C1OC(O)C(N)C(O)C1O;NSC283301;AKOS009031374;NSC-283301;SB46976;.beta.-D-Galactopyranose, hydrochloride;PD056345;SY011489;Galactopyranose, hydrochloride, .beta.-D-;EN300-20118;2-Amino-2-deoxyhexopyranose--hydrogen chloride (1/1);3-amino-6-(hydroxymethyl)oxane-2,4,5-triolHydrochloride;.beta.-D-Galactopyranose, 2-amino-2-deoxy-, hydrochloride;Galactopyranose, 2-amino-2-deoxy-, hydrochloride, .beta.-D-

Chemical Property of 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 5.53E-10mmHg at 25°C
• Melting Point: 190-194 °C (dec.)(lit.)
• Refractive Index: 72 ° (C=1, H2O)
• Boiling Point: 449.9 °C at 760 mmHg
• Flash Point: 225.9 °C
• PSA: 124.01000
• LogP: -1.91010
• Storage Temp.: Store at RT.
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 215.0560502
• Heavy Atom Count: 13
• Complexity: 155

Purity/Quality:

99%, ^*data from raw suppliers

D-Glucosamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn, F
• Hazard Codes: F,Xi,Xn
• Statements: 21-36/38-46-62-63
• Safety Statements: 24/25-53-36/37-26-25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Biological Agents -> Monosaccharides and Derivatives
• Canonical SMILES: C(C1C(C(C(C(O1)O)N)O)O)O.Cl
• Recent ClinicalTrials: Effects of Oral Glucosamine on Insulin and Blood Vessel Activity in Normal and Obese People
• Recent EU Clinical Trials: Evaluation of the evolution of imaging markers of cartilage degradation in patients with knee osteoarthritis receiving DROGLICAN?: a Pilot Study
• Recent NIPH Clinical Trials: Investigation of blood kinetics at the time of ingestion of coating processed glucosamine hydrochloride
• Uses: Novel application of D-Glucosamine hydrochloride to prepare medical agent for treating vertigo. Found in chitin, in mucoproteins, and in mucopolysaccharides. Antiarthritic. Recent studies show that its chondroprotective activity is related to its antiapoptic properties. glucosamine hydrochloride (glucosamine HCl) is used to adjust the pH of a formulation. It also has anti-static and hair-conditioning properties. Novel application of glucosamine is to prepare medical agent for treating vertigo. It is used as food ingredients and additives, raw material for anti cancer and antibiotic drugs.

Technology Process of 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride

There total 7 articles about 3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

entagenic acid 3-O-β-D-xylopyranosyl-(1->3)-β-D-glucopyranosyl(1->6)-O-[β-D-xylopyranosyl(1->3)]-2-acetylamino-2-deoxy-β-D-glucopyranoside 28-O-[β-D-xylopyranosyl(1->2), β-D-apiofuranosyl(1->3)]-β-D-glucopyranosyl ester → D-xylose (58-86-6) + D-apiose (639-97-4,6477-44-7,42927-70-8) + D-glucose (50-99-7) + 3β,15α,16α-trihydroxy-18β-olean-12-en-28-oic acid (5951-41-7) + D-(+)-glucosamine hydrochloride (66-84-2)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1248/cpb.59.466

Reference yield:

entagenic acid 3-O-β-D-xylopyranosyl-(1->2)-α-L-arabinopyranosyl(1->6)-2-acetylamino-2-deoxy-β-D-glucopyranoside 28-O-[β-D-xylopyranosyl(1->2), β-D-apiofuranosyl(1->3)]-6-acetyl-β-D-glucopyranosyl ester → D-xylose (58-86-6) + D-apiose (639-97-4,6477-44-7,42927-70-8) + L-arabinose (5328-37-0) + D-glucose (50-99-7) + 3β,15α,16α-trihydroxy-18β-olean-12-en-28-oic acid (5951-41-7) + D-(+)-glucosamine hydrochloride (66-84-2)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1248/cpb.59.466

Reference yield:

→ 2-amino-2-deoxy-D-galactose hydrochloride (66-84-2,1772-03-8,2861-47-4,4773-26-6,5505-63-5,20880-44-8,25591-10-0,28002-39-3,91673-93-7,91674-20-3,91674-21-4,92986-85-1,95245-33-3,113532-33-5)

Guidance literature:

Diacetat VII, Eg., H2, HCl;

upstream raw materials:

3-O-β-D-xylopyranosyl-(1->2)-β-D-galactopyranosyl-(1->6)-2-acetamido-2-deoxy-β-D-glucopyranosyl echinocystic acid 16-O-β-D-glucopyranoside

Downstream raw materials:

2-acetamido-2-deoxy-D-glucose

N-benzoylglucosamine

N-benzoyl-α-D-glucosamine

tetra-O-benzoyl-2-benzoylamino-2-deoxy-β-D-glucopyranose

Refernces

• 1、 Miyase, Toshio,Melek,Ghaly,Warashina, Tsutomu,El-Kady,Nabil, Marian. "Echinocystic acid 3,16-O-bisglycosides from Albizia procera". experimental part. p. 1375 - 1380. Retrieved 2011/05/17.