methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Base Information

Chemical Name:methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate
CAS No.:1268385-50-7
Molecular Formula:C₁₆H₁₄F₃NO₃
Molecular Weight:325.287
Hs Code.:

Synonyms:methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Chemical Property of methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Technology Process of methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

There total 8 articles about methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1268385-49-4
{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic acid

: 75-36-5
acetyl chloride

: 1268385-50-7
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: In methanol; at 65 ℃;

Reference yield: 98.0%

: 67-56-1
methanol

: 1268385-49-4
{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic acid

: 1268385-50-7
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: With chloro-trimethyl-silane; at 64 ℃; for 3.5h; Inert atmosphere;
DOI:10.1021/jo4014595

Reference yield:

: 1268385-47-2
2-{3-[4-bromo-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol

: 1268385-50-7
methyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 55 °C / Inert atmosphere

2.1: periodic acid / acetonitrile / 2 - 20 °C

2.2: 2 - 20 °C

3.1: methanol / 65 °C

With periodic acid; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; water; toluene; acetonitrile;