3-Propanoyldihydrofuran-2(3h)-one

Base Information

• Chemical Name: 3-Propanoyldihydrofuran-2(3h)-one
• CAS No.: 23938-71-8
• Molecular Formula: C7H10 O3
• Molecular Weight: 142.1525
• NSC Number: 118140
• DSSTox Substance ID: DTXSID40297790
• Mol file: 23938-71-8.mol

Synonyms:23938-71-8;3-propanoyldihydrofuran-2(3h)-one;NSC118140;2(3H)-Furanone, dihydro-3-(1-oxopropyl)-;SCHEMBL535753;DTXSID40297790;NMBNELUCVZVUCO-UHFFFAOYSA-N;3-propionyldihydrofuran-2(3H)-one;NSC-118140

Chemical Property of 3-Propanoyldihydrofuran-2(3h)-one

Chemical Property:

• Vapor Pressure: 0.00169mmHg at 25°C
• Boiling Point: 293.8°Cat760mmHg
• Flash Point: 131°C
• Density: 1.146g/cm³
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 142.062994177
• Heavy Atom Count: 10
• Complexity: 162

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)C1CCOC1=O

Technology Process of 3-Propanoyldihydrofuran-2(3h)-one

There total 4 articles about 3-Propanoyldihydrofuran-2(3h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

4-butanolide (96-48-0) + propionyl chloride (79-03-8) → 2-propionyl-γ-butyrolactone (23938-71-8)

Guidance literature:

4-butanolide; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; benzene; at -78 ℃; for 1h;

propionyl chloride; In tetrahydrofuran; n-heptane; benzene; at -78 - -70 ℃; for 0.25h;

Reference yield: 34.0%

4-butanolide (96-48-0) + propanoic acid methyl ester (554-12-1) → 2-propionyl-γ-butyrolactone (23938-71-8)

Guidance literature:

4-butanolide; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -50 ℃; for 1h;

propanoic acid methyl ester; In tetrahydrofuran; hexane; at 20 ℃; Further stages.;

DOI:10.1016/j.bmcl.2007.11.101

Reference yield:

4-butanolide (96-48-0) + Ethyl propionate (105-37-3,20741-13-3) → 2-propionyl-γ-butyrolactone (23938-71-8)

Guidance literature:

With sodium;

DOI:10.1021/ja01556a045

upstream raw materials:

4-butanolide

Ethyl propionate

propanoic acid methyl ester

propionyl chloride

Downstream raw materials:

6-bromo-3-hexanone

(4-oxohexyl)triphenylphosphonium iodide

3-(2-ethyl-1,3-dioxolan-2-yl)propyltriphenylphosphonium iodide

tert-butyl (S)-((R)-2-oxo-3-propionyltetrahydrofuran-3-yl)(phenyl)methylcarbamate