Ethyl 5-benzyloxazole-4-carboxylate

Base Information Edit

Chemical Name:Ethyl 5-benzyloxazole-4-carboxylate
CAS No.:32998-96-2
Molecular Formula:C₁₃H₁₃NO₃
Molecular Weight:231.251
Hs Code.:
DSSTox Substance ID:DTXSID801262801
Nikkaji Number:J3.428.727I
Mol file:32998-96-2.mol

Synonyms:SCHEMBL12138862;HKTCARWISGVHPQ-UHFFFAOYSA-N;DTXSID801262801;ethyl 5-benzyloxazole-4-carboxylate;32998-96-2;Ethyl 5-(phenylmethyl)-4-oxazolecarboxylate;Ethyl 5-benzyloxazole-4-carboxylate, AldrichCPR

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 5-benzyloxazole-4-carboxylate Edit

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:231.08954328
Heavy Atom Count:17
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(OC=N1)CC2=CC=CC=C2

Technology Process of Ethyl 5-benzyloxazole-4-carboxylate

There total 6 articles about Ethyl 5-benzyloxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 23012-14-8
oxazole-4-carboxylic acid ethyl ester

: 100-44-7
benzyl chloride

: 68485-14-3
ethyl 2-benzyloxazole-4-carboxylate

: 32998-96-2
ethyl 5-benzyloxazole-4-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; CyJohnPhos; In 1,4-dioxane; at 110 ℃; for 18h; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/b816374j

Reference yield: 33.0%

: 2999-46-4
Ethyl isocyanoacetate

: 156-06-9
2-oxo-3-(phenyl)propionic acid

: 32998-96-2
ethyl 5-benzyloxazole-4-carboxylate

Guidance literature:: 2-oxo-3-(phenyl)propionic acid; With potassium hydroxide; In isopropyl alcohol; Schlenk technique;

Ethyl isocyanoacetate; With dipotassium peroxodisulfate; 1,10-Phenanthroline; silver carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c5cc02253c