N,N-dimethyl-α-(m-methoxyphenyl)ethylamine

Base Information

• Chemical Name: N,N-dimethyl-α-(m-methoxyphenyl)ethylamine
• CAS No.: 129052-92-2
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.262
• Mol file: 129052-92-2.mol

Synonyms:N,N-dimethyl-α-(m-methoxyphenyl)ethylamine

Chemical Property of N,N-dimethyl-α-(m-methoxyphenyl)ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-α-(m-methoxyphenyl)ethylamine

There total 7 articles about N,N-dimethyl-α-(m-methoxyphenyl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N-dimethylthioformamide (758-16-7) + (3-methoxyphenyl)magnesium bromide (36282-40-3) + methyllithium (917-54-4) → N,N-dimethyl-α-(m-methoxyphenyl)ethylamine (129052-92-2)

Guidance literature:

N,N-dimethylthioformamide; methyllithium; In tetrahydrofuran; diethyl ether; cyclohexane; at -78 - 20 ℃;

(3-methoxyphenyl)magnesium bromide; In tetrahydrofuran; diethyl ether; cyclohexane; at 20 ℃; for 2h;

DOI:10.1021/ja068523f

Reference yield: 61.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 1-(3-Methoxyphenyl)ethanone (586-37-8) → N,N-dimethyl-α-(m-methoxyphenyl)ethylamine (129052-92-2)

Guidance literature:

With trifluorormethanesulfonic acid; water; at 60 ℃; for 12h; Temperature; Time; Inert atmosphere;

DOI:10.1039/d0cc02955f

Reference yield: 60.0%

dimethyl amine (124-40-3) + 1-(3-Methoxyphenyl)ethanone (586-37-8) → N,N-dimethyl-α-(m-methoxyphenyl)ethylamine (129052-92-2)

Guidance literature:

dimethyl amine; 1-(3-Methoxyphenyl)ethanone; With titanium(IV) isopropylate; In ethanol; at 10 - 35 ℃; for 9 - 10h;

With sodium tetrahydroborate; In ethanol; at 20 - 30 ℃; for 12 - 14h;

upstream raw materials:

1-(3-methoxy)-phenylethanol

N,N-dimethylammonium chloride

1-(3-Methoxyphenyl)ethanone

1-chloro-1-(3'-methoxyphenyl)ethane

Downstream raw materials:

methyl-carbamic acid-[3-(1-dimethylamino-ethyl)-phenyl ester]

(+/-)-1H-1-hydroxy-2,3-dihydro-2,2,3-trimethyl-7-methoxyisoindolium picrate

(+/-)-1H-1-hydroxy-2,3-dihydro-2,2,3-trimethyl-7-methoxyisoindolium 3,5-dinitrobenzoate

methiodide of (+/-)-N,N-dimethyl-α-(2-formyl-3-methoxyphenyl)ethylamine