2-(4-acetamidophenyl)propanoic acid

Base Information

• Chemical Name: 2-(4-acetamidophenyl)propanoic acid
• CAS No.: 99701-07-2
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 99701-07-2.mol

Synonyms:2-(4-acetamidophenyl)propanoic acid

Chemical Property of 2-(4-acetamidophenyl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-acetamidophenyl)propanoic acid

There total 5 articles about 2-(4-acetamidophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

carbon dioxide (124-38-9,18923-20-1) + N-(4-ethylphenyl)acetamide (3663-34-1) → 2-(4-acetamidophenyl)propanoic acid (99701-07-2)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; triisopropylsilanethiol; In N,N-dimethyl-formamide; at 0 ℃; for 24h; under 3040.2 Torr; Irradiation; Sealed tube;

DOI:10.1021/jacs.9b05360

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + N-(4-vinyl-phenyl)-acetamide (53498-47-8) → 2-(4-acetamidophenyl)propanoic acid (99701-07-2)

Guidance literature:

With manganese; nickel(II) chloride hexahydrate; 4,4’-di-tert-butyl-6-methyl-2,2’-bipyridine; water; In N,N-dimethyl acetamide; at 0 ℃; under 760.051 Torr; chemoselective reaction; Schlenk technique;

DOI:10.1021/jacs.7b07637

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2-bromo-1-[4-(acetylamino)phenyl]-ethane (39232-06-9) → 3-(4-acetamidophenyl)propanoic acid (6325-43-5) + 2-(4-acetamidophenyl)propanoic acid (99701-07-2)

Guidance literature:

With neocuproine; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; under 750.075 Torr; Overall yield = 65 %; Overall yield = 27 mg; Irradiation;

DOI:10.1002/chem.201902095

upstream raw materials:

acetic anhydride

carbon dioxide

N-(4-vinyl-phenyl)-acetamide

2-bromo-1-[4-(acetylamino)phenyl]-ethane

Downstream raw materials:

(±)-methyl 2-(4-acetamidophenyl)propanoate