4-PHENYL-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-PHENYL-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 79247-92-0
• Molecular Formula: C₁₁H₉NO₂S
• Molecular Weight: 219.264
• Mol file: 79247-92-0.mol

Synonyms:ETHYL 4-PHENYLTHIAZOLE-2-CARBOXYLATE;2-Thiazolecarboxylic acid,4-phenyl-,methyl ester;ethyl 4-phenyl-1,3-thiazole-2-carboxylate;Methyl 4-phenylthiazole-2-carboxylate

Chemical Property of 4-PHENYL-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 369.9 °C at 760 mmHg
• Flash Point: 177.5 °C
• PSA: 67.43000
• Density: 1.216 g/cm³
• LogP: 2.59670
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-phenyl-2-thiazolecarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PHENYL-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER

There total 4 articles about 4-PHENYL-THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester (7113-02-2) → methyl 4-phenylthiazole-2-carboxylate (79247-92-0) + methyl 3-phenyl-1,2-thiazole-5-carboxylate (68438-26-6)

Guidance literature:

In acetonitrile; Irradiation;

DOI:10.1016/S0040-4039(00)87815-6

Reference yield:

acetophenone (98-86-2) → methyl 4-phenylthiazole-2-carboxylate (79247-92-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 0.5 h / Heating

2: KOH, water / 0.08 h / Heating

3: H₂SO₄ / 240 h / 20 °C

With potassium hydroxide; sulfuric acid; water; In ethanol;

DOI:10.1039/P19810002335

Reference yield:

methanol (67-56-1) + 4-phenylthiazole-2-carboxylic acid (59020-44-9) → methyl 4-phenylthiazole-2-carboxylate (79247-92-0)

Guidance literature:

With sulfuric acid; at 20 ℃; for 240h;

DOI:10.1039/P19810002335

upstream raw materials:

methanol

4-phenylthiazole-2-carboxylic acid

2-phenyl-1,3-thiazole-4-carboxylic acid methyl ester

ethyl 4-phenyl-1,3-thiazole-2-carboxylate

Downstream raw materials:

4-Phenyl-thiazole-2-carbothioic acid amide