3-hydroxy-5-acetoxy iodobenzene

Base Information

• Chemical Name: 3-hydroxy-5-acetoxy iodobenzene
• CAS No.: 167764-54-7
• Molecular Formula: C₈H₇IO₃
• Molecular Weight: 278.046
• Mol file: 167764-54-7.mol

Synonyms:3-hydroxy-5-acetoxy iodobenzene

Chemical Property of 3-hydroxy-5-acetoxy iodobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-5-acetoxy iodobenzene

There total 4 articles about 3-hydroxy-5-acetoxy iodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(diacetoxyiodo)benzene diacetate (167764-53-6) → 3-hydroxy-5-acetoxy iodobenzene (167764-54-7)

Guidance literature:

With potassium hydroxide; In ethanol; benzene; at 0 ℃; for 0.5h;

DOI:10.1016/0968-0896(96)00060-0

Reference yield:

1-iodo-3,5-dimethoxybenzene (25245-27-6) → 3-hydroxy-5-acetoxy iodobenzene (167764-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / BBr₃ / CH₂Cl₂ / -20 - 20 °C

2: 96 percent / Et₃N / CH₂Cl₂

3: 72 percent / KOH / benzene; ethanol / 0.5 h / 0 °C

With potassium hydroxide; boron tribromide; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0968-0896(96)00060-0

Reference yield:

5-iodoresorcinol (64339-43-1) → 3-hydroxy-5-acetoxy iodobenzene (167764-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N / CH₂Cl₂

2: 72 percent / KOH / benzene; ethanol / 0.5 h / 0 °C

With potassium hydroxide; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0968-0896(96)00060-0

upstream raw materials:

(diacetoxyiodo)benzene diacetate

1-iodo-3,5-dimethoxybenzene

5-iodoresorcinol

3.5-dimethoxyaniline

Downstream raw materials:

Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester

[3'-[2-(4-Fluoro-phenyl)-ethoxy]-4-(3-methyl-butoxy)-5'-(2-morpholin-4-yl-ethoxy)-biphenyl-3-yl]-methanol