Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester

Base Information

• Chemical Name: Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester
• CAS No.: 180135-48-2
• Molecular Formula: C₁₄H₂₁IO₃Si
• Molecular Weight: 392.309
• Mol file: 180135-48-2.mol

Synonyms:Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester

Chemical Property of Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester

There total 5 articles about Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 3-hydroxy-5-acetoxy iodobenzene (167764-54-7) → Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester (180135-48-2)

Guidance literature:

With 1H-imidazole; In dichloromethane; at -5 - 20 ℃;

DOI:10.1016/0968-0896(96)00060-0

Reference yield:

1-iodo-3,5-dimethoxybenzene (25245-27-6) → Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester (180135-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / BBr₃ / CH₂Cl₂ / -20 - 20 °C

2: 96 percent / Et₃N / CH₂Cl₂

3: 72 percent / KOH / benzene; ethanol / 0.5 h / 0 °C

4: 91 percent / imidazole / CH₂Cl₂ / -5 - 20 °C

With 1H-imidazole; potassium hydroxide; boron tribromide; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0968-0896(96)00060-0

Reference yield:

5-iodoresorcinol (64339-43-1) → Acetic acid 3-(tert-butyl-dimethyl-silanyloxy)-5-iodo-phenyl ester (180135-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N / CH₂Cl₂

2: 72 percent / KOH / benzene; ethanol / 0.5 h / 0 °C

3: 91 percent / imidazole / CH₂Cl₂ / -5 - 20 °C

With 1H-imidazole; potassium hydroxide; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/0968-0896(96)00060-0

upstream raw materials:

tert-butyldimethylsilyl chloride

3-hydroxy-5-acetoxy iodobenzene

1-iodo-3,5-dimethoxybenzene

5-iodoresorcinol

Downstream raw materials:

[3'-[2-(4-Fluoro-phenyl)-ethoxy]-4-(3-methyl-butoxy)-5'-(2-morpholin-4-yl-ethoxy)-biphenyl-3-yl]-methanol