1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene

Base Information

• Chemical Name: 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene
• CAS No.: 1281971-25-2
• Molecular Formula: C₁₂H₁₀F₂O₂
• Molecular Weight: 224.207
• Mol file: 1281971-25-2.mol

Synonyms:1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene

Chemical Property of 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene

There total 10 articles about 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

ethanol (64-17-5) + C14H13F2NO2 → 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene (1281971-25-2)

Guidance literature:

With chloro-trimethyl-silane; at 80 ℃; for 24h; Sealed tube;

DOI:10.1055/a-1750-8314

Reference yield: 77.0%

copper(I) phenylacetylenide (13146-23-1) + Ethyl bromodifluoroacetate (667-27-6) → 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene (1281971-25-2)

Guidance literature:

With 1,10-Phenanthroline; copper diacetate; cesium pivalate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Reagent/catalyst; Solvent; Time;

DOI:10.1002/ejoc.201402937

Reference yield: 75.0%

1-Decene (872-05-9,17438-89-0,25189-70-2) + Ethyl bromodifluoroacetate (667-27-6) + 1-methyl-4-((phenylethynyl)sulfonyl)benzene (28995-88-2) → 1-phenyl-2-ethoxyldifluoromethylcarbonyl acetylene (1281971-25-2) + C22H30F2O2

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 36h; Reagent/catalyst; Solvent; Irradiation; Inert atmosphere;

DOI:10.1039/c8cc03105c

upstream raw materials:

chloroformic acid ethyl ester

bromodifluoromethylphenylacetylene

copper(I) phenylacetylenide

Ethyl bromodifluoroacetate

Downstream raw materials:

N-methoxy-N-methyl-2,2-difluoro-4-phenyl-3-butynamide