(2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

Base Information

Chemical Name:(2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide
CAS No.:914936-57-5
Molecular Formula:C₃₆H₆₂O₅
Molecular Weight:574.885
Hs Code.:

Synonyms:(2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

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Chemical Property of (2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

Chemical Property:

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Technology Process of (2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

There total 14 articles about (2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 914936-55-3
(2S)-24,28-dihydroxy-2-(p-methoxybenzyloxy)octacosanoic acid

: 914936-57-5
(2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

Guidance literature:: With 2-methyl-6-nitrobenzoic anhydride; triethylamine; 4-(dimethylamino)pyridine N-oxide; In tetrahydrofuran; dichloromethane; at 50 ℃; for 12h;
DOI:10.1021/ol062011o

Reference yield:

: 915024-77-0
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

: 914936-57-5
(2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / acetic acid; TBAF / tetrahydrofuran / 22.5 h / 20 °C

2: TEMPO; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer; H₂O / 8.5 h / 20 °C

3: 262.3 mg / aq. HCl / tetrahydrofuran / 71 h / 20 °C

4: 77 percent / 2-methyl-6-nitrobenzoic anhydride; triethylamine / 4-(dimethylaminopyridine) N-oxide / CH₂Cl₂; tetrahydrofuran / 12 h / 50 °C

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; 2-methyl-6-nitrobenzoic anhydride; tetrabutyl ammonium fluoride; acetic acid; triethylamine; 4-(dimethylamino)pyridine N-oxide; In tetrahydrofuran; phosphate buffer; dichloromethane; water; acetonitrile;
DOI:10.1021/ol062011o

Reference yield:

: 915024-78-1
(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

: 914936-57-5
(2S)-24-hydroxy-2-(p-methoxybenzyloxy)octacosanolide

Guidance literature:: Multi-step reaction with 3 steps

1: TEMPO; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer; H₂O / 8.5 h / 20 °C

2: 262.3 mg / aq. HCl / tetrahydrofuran / 71 h / 20 °C

3: 77 percent / 2-methyl-6-nitrobenzoic anhydride; triethylamine / 4-(dimethylaminopyridine) N-oxide / CH₂Cl₂; tetrahydrofuran / 12 h / 50 °C

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; 2-methyl-6-nitrobenzoic anhydride; triethylamine; 4-(dimethylamino)pyridine N-oxide; In tetrahydrofuran; phosphate buffer; dichloromethane; water; acetonitrile;
DOI:10.1021/ol062011o