(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

Base Information

Chemical Name:(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol
CAS No.:915024-78-1
Molecular Formula:C₄₆H₈₂O₇
Molecular Weight:747.153
Hs Code.:

Synonyms:(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

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Technology Process of (2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

There total 13 articles about (2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 915024-77-0
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosane

: 915024-78-1
(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 22.5h;
DOI:10.1021/ol062011o

Reference yield:

: 914936-51-9
(2S)-1-(t-butyldiphenylsiloxy)-2-(p-methoxybenzyloxy)-28-(tetrahydro-2H-pyran-2-yloxy)octacosane-24-ol

: 915024-78-1
(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

2: 96 percent / acetic acid; TBAF / tetrahydrofuran / 22.5 h / 20 °C

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol062011o

Reference yield:

: 914936-39-3
(2S)-1-(t-butyldiphenylsiloxy)-4-iodo-2-(p-methoxybenzyloxy)butane

: 915024-78-1
(2S)-2-(p-methoxybenzyloxy)-24,28-di(tetrahydro-2H-pyran-2-yloxy)octacosanol

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / cuprous(I) iodide; 2,2'-bipyridyl / tetrahydrofuran / -20 - 20 °C

2: 96 percent / aq. HCl / tetrahydrofuran / 6 h / 20 °C

3: 92 percent / imidazole; triphenylphosphine; iodine / benzene / 0.5 h / 20 °C

4: 96 percent / cuprous(I) iodide; 2,2'-bipyridyl / tetrahydrofuran / -17 - 20 °C

5: 99 percent / aq. HCl / tetrahydrofuran / 6 h / 20 °C

6: 85 percent / PCC / CH₂Cl₂ / 22 h / 20 °C

7: 81 percent / tetrahydrofuran / 1.5 h / 0 °C

8: 86 percent / p-toluenesulfonic acid monohydrate / CH₂Cl₂ / 2 h / 20 °C

9: 96 percent / acetic acid; TBAF / tetrahydrofuran / 22.5 h / 20 °C

With 1H-imidazole; hydrogenchloride; [2,2]bipyridinyl; copper(l) iodide; tetrabutyl ammonium fluoride; iodine; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol062011o