3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96%
• CAS No.: 890839-37-9
• Molecular Formula: C₁₃H₁₇BF₂O₃
• Molecular Weight: 270.084
• Mol file: 890839-37-9.mol

Synonyms:2-(3,5-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96%

Chemical Property:

• Boiling Point: 332.2±42.0 °C(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

3,5-Difluoro-4-methoxybenzeneboronic acid pinacol ester, 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96%

There total 5 articles about 3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-1,3-difluoro-2-methoxy-benzene (104197-14-0) + bis(pinacol)diborane (73183-34-3) → 2-(3,5-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (890839-37-9)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; at 80 ℃; for 12.5h; Inert atmosphere;

Reference yield:

2,6-difluorophenol (28177-48-2) → 2-(3,5-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (890839-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 h / 0 - 20 °C

2: potassium carbonate / acetone / 22 h / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; 1,4-dioxane / 12.5 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

4-bromo-2,6-difluorophenol (104197-13-9) → 2-(3,5-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (890839-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 22 h / 0 - 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dichloromethane; 1,4-dioxane / 12.5 h / 80 °C / Inert atmosphere

With potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; acetone;

upstream raw materials:

5-bromo-1,3-difluoro-2-methoxy-benzene

bis(pinacol)diborane

2,6-difluorophenol

4-bromo-2,6-difluorophenol

Downstream raw materials:

2-((4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

2-((4-amino-3-(3,5-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

2-(1-(4-amino-3-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

2-(1-(4-amino-3-(3,5-difluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

Refernces

• 1、 Jain, Rama,Mathur, Michelle,Lan, Jiong,Costales, Abran,Atallah, Gordana,Ramurthy, Savithri,Subramanian, Sharadha,Setti, Lina,Feucht, Paul,Warne, Bob,Doyle, Laura,Basham, Stephen,Jefferson, Anne B.,Lindvall, Mika,Appleton, Brent A.,Shafer, Cynthia M.. "Discovery of Potent and Selective RSK Inhibitors as Biological Probes". . p. 6766 - 6783. Retrieved 2015/09/22.
• 2、 -. "NOVEL KINASE MODULATORS". Page/Page column 100. . Retrieved 2011/06/10.