4-(Hydroxymethyl)-2-methoxy-5-nitrophenol

Base Information

Chemical Name:4-(Hydroxymethyl)-2-methoxy-5-nitrophenol
CAS No.:260417-00-3
Molecular Formula:C₈H₉NO₅
Molecular Weight:199.163
Hs Code.:
European Community (EC) Number:845-589-2

Synonyms:4-(hydroxymethyl)-2-methoxy-5-nitrophenol;260417-00-3;SCHEMBL13284232;AKOS011349892;CS-0242670;EN300-253657;Z944942302

Suppliers and Price of 4-(Hydroxymethyl)-2-methoxy-5-nitrophenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-(Hydroxymethyl)-2-methoxy-5-nitrophenol

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:199.04807239
Heavy Atom Count:14
Complexity:204

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)CO)[N+](=O)[O-])O

Technology Process of 4-(Hydroxymethyl)-2-methoxy-5-nitrophenol

There total 6 articles about 4-(Hydroxymethyl)-2-methoxy-5-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2454-72-0
6-nitrovanillin

: 260417-00-3
4-(hydroxymethyl)-2-methoxy-5-nitrophenol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 25 ℃; for 24h;
DOI:10.1016/j.bmcl.2006.05.035

Reference yield: 27.0%

: 67-56-1
methanol

: 124-41-4
sodium methylate

: 712-97-0
6-nitro-1,3-benzodioxole-5-carbaldehyde

: 260417-00-3
4-(hydroxymethyl)-2-methoxy-5-nitrophenol

Guidance literature:: 6-nitro-1,3-benzodioxole-5-carbaldehyde; With sodium tetrahydroborate; ethanol; at 0 ℃; for 3h;

methanol; sodium methylate; In dimethyl sulfoxide; at 120 ℃; for 2h;
DOI:10.1021/jacs.9b11969

Reference yield:

: 121-33-5,8014-42-4
vanillin

: 260417-00-3
4-(hydroxymethyl)-2-methoxy-5-nitrophenol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 15 h / 90 °C / Inert atmosphere

2: acetic acid; nitric acid / 25 °C / Cooling with ice

3: trifluoroacetic acid / 25 °C / Inert atmosphere

4: sodium tetrahydroborate / ethanol / 25 °C

With sodium tetrahydroborate; nitric acid; potassium carbonate; acetic acid; trifluoroacetic acid; In ethanol; dimethyl sulfoxide;
DOI:10.1039/c5nj03173g