1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

Base Information

Chemical Name:1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol
CAS No.:956109-61-8
Molecular Formula:C₁₇H₁₅BrF₂N₂O₂
Molecular Weight:397.219
Hs Code.:

Synonyms:1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

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Chemical Property of 1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

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Technology Process of 1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

There total 3 articles about 1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1244783-77-4
1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)propan-2-one

: 676-58-4
methylmagnesium chloride

: 956109-61-8
1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: 1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)propan-2-one; methylmagnesium chloride; In tetrahydrofuran; toluene; at 34 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; toluene; for 0.333333h; Product distribution / selectivity;

Reference yield: 36.4%

: 558-30-5
2-methyl-1,2-epoxypropane

: 765914-74-7
6-bromo-5-(2,4-difluorophenoxy)-1H-indazole

: 956109-61-8
1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: With potassium carbonate; In ISOPROPYLAMIDE; at 55 - 80 ℃; for 16 - 22h; Product distribution / selectivity;

Reference yield:

: 1244783-75-2
5-bromo-4-(2,4-difluorophenoxy)-2-methylbenzenediazonium tetrafluoroborate

: 956109-61-8
1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / ethyl acetate / 1.5 h / 20 °C

2: potassium carbonate / ISOPROPYLAMIDE / 16 - 22 h / 55 - 80 °C

With potassium acetate; potassium carbonate; In ISOPROPYLAMIDE; ethyl acetate;