(1-Benzylindazol-3-yl)methanol

Base Information

• Chemical Name: (1-Benzylindazol-3-yl)methanol
• CAS No.: 131427-21-9
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• European Community (EC) Number: 603-485-2
• DSSTox Substance ID: DTXSID70443142
• Wikidata: Q82260853
• Mol file: 131427-21-9.mol

Synonyms:131427-21-9;(1-benzylindazol-3-yl)methanol;(1-Benzyl-1H-indazol-3-yl)methanol;1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE;EC 603-485-2;1H-Indazole-3-methanol,1-(phenylmethyl)-;SCHEMBL928055;1-benzyl-3-hydroxymethylindazole;1-benzyl3-hydroxymethyl-indazole;DTXSID70443142;1-benzyl-3-hydroxymethyl-indazole;AKQDXNFPEFHRLS-UHFFFAOYSA-N;2-METHOXYPHENYLGLYOXALHYDRATE;AKOS015911451;(1-Benzyl-1H-indazol-3-yl) methanol;(1-Benzyl-1H-indazol-3-yl)-methanol;SB16311;BS-20503;CS-0210684;FT-0749713

Chemical Property of (1-Benzylindazol-3-yl)methanol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.633
• Boiling Point: 450.624 °C at 760 mmHg
• Flash Point: 226.33 °C
• PSA: 38.05000
• Density: 1.183 g/cm³
• LogP: 2.57690
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

99.9% ^*data from raw suppliers

(1-Benzyl-1H-indazol-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)CO

Technology Process of (1-Benzylindazol-3-yl)methanol

There total 16 articles about (1-Benzylindazol-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-benzyl-1H-indazole-3-carbaldehyde (1186509-61-4) → (1-Benzyl-1H-indazol-3-yl)-methanol (131427-21-9)

Guidance literature:

1-benzyl-1H-indazole-3-carbaldehyde; With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 20 ℃; for 0.25h; Inert atmosphere;

With hydrogenchloride; water; In toluene;

Reference yield: 79.6%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-benzyl-3-iodo-1H-indazole (205643-28-3) → (1-Benzyl-1H-indazol-3-yl)-methanol (131427-21-9)

Guidance literature:

N-benzyl-3-iodo-1H-indazole; With isopropylmagnesium chloride; In 2-methyltetrahydrofuran; at -10 ℃; for 2h; Inert atmosphere;

formaldehyd; In 2-methyltetrahydrofuran; at 0 ℃; for 2h;

With phosphoric acid; In 2-methyltetrahydrofuran;

Reference yield: 71.0%

benzyl bromide (100-39-0) + 3-(hydroxymethyl)-1H-indazole (64132-13-4) → (1-Benzyl-1H-indazol-3-yl)-methanol (131427-21-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

upstream raw materials:

1-Benzyl-1H-indazole-3-carboxylic acid benzyl ester

1H-Indazole-3-carboxylic acid

ethyl 2-hydroxypropionate

1-benzyl-3-chloromethyl-1H-indazole

Downstream raw materials:

[1-(4-methoxybenzyl)-1H-indazol-3-yl]methanol

2-[(1-benzyl-1H-indazol-3-yl)methoxy]-N,N-dimethylethanamine

1-benzyl-1H-indazole-3-carbaldehyde

1-benzyl-3-chloromethyl-1H-indazole